Effects of a supplement on skin and inflammation in rosacea
The Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea
This study is testing whether an oral supplement with L-Histidine and antioxidants can help people with mild to moderate rosacea improve their skin and reduce inflammation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 30 Years to 70 Years |
| Sex | All |
| Sponsor | Integrative Skin Science and Research Industry-sponsored |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT06072066 on ClinicalTrials.gov |
What this trial studies
This study evaluates the impact of an oral supplement containing L-Histidine and antioxidants on skin barrier function and systemic inflammation in individuals with rosacea. It aims to determine whether this supplementation can improve both gut and skin barrier integrity while reducing inflammation levels. Participants will be monitored for changes in their condition over the course of the study, focusing on those with mild to moderate rosacea. The study is designed to provide insights into the relationship between dietary supplementation and skin health.
Who should consider this trial
Good fit: Ideal candidates are males and females aged 30 to 70 with mild to moderate rosacea and elevated levels of high sensitivity C-reactive protein.
Not a fit: Patients with severe rosacea or those currently using certain medications or supplements may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of rosacea and enhanced skin health for affected patients.
How similar studies have performed: While there is ongoing research into dietary supplements for skin conditions, this specific approach combining L-Histidine and antioxidants in rosacea is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Males and females 30 to 70 years of age * The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular) * High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg/L Exclusion Criteria: * The presence of severe rosacea as noted by the investigator global assessment. * Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment. * Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment * Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment. * Those who are unwilling to keep their facial regimen the same throughout the study. * Individuals who have been on an oral antibiotic within the previous one month. * Individuals who are pregnant or breastfeeding. * Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study. * Individuals on oral contraceptive pills or progesterone or estrogen containing therapies. * Use of isotretinoin within the three months prior to enrollment. * Individuals on finasteride or dutasteride * Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.
Where this trial is running
Sacramento, California
- Integrative Skin and Research — Sacramento, California, United States (Recruiting)
Study contacts
- Study coordinator: Caitlin Egli
- Email: research@integrativeskinresearch.com
- Phone: 916-750-2463
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.