Effects of a nitrate mouth rinse on the oral microbiome
Nitrate Mouth Rinse and the Oral Microbiome
This study is testing if a mouth rinse made from beetroot can change the bacteria in your mouth and improve your overall health for people aged 18 to 40.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Dalhousie University Academic / other |
| Locations | 1 site (Halifax, Nova Scotia) |
| Trial ID | NCT06588049 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of a nitrate-rich mouth rinse, derived from beetroot, on the composition of the oral microbiome. Participants aged 18 to 40 will use either the nitrate mouth rinse or a control water rinse daily for two weeks while maintaining their regular oral hygiene. The study will analyze changes in the oral microbiome using 16s rRNA sequencing and will also measure salivary nitric oxide levels and blood pressure before and after the intervention. The goal is to enhance understanding of how oral hygiene products affect both oral and systemic health.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18 to 40 with no uncontrolled systemic diseases.
Not a fit: Patients with uncontrolled systemic diseases, acute infections, or significant oral health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved formulations of oral hygiene products that enhance oral and systemic health.
How similar studies have performed: While the specific approach of using a nitrate mouth rinse is novel, related studies on dietary nitrates and health have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * You are between the ages of 18 and 40. Have no uncontrolled systemic diseases. Participants with mild chronic conditions such as: * Asthma * Type 1 Diabetes Mellitus Exclusion Criteria: * You are under the age of 18. * You have uncontrolled systemic diseases, or acute infections. * You are taking prescription, antibiotics, probiotics, or antimicrobial mouthrinses. * You have a documented true allergy (i.e Hives, Swelling of lips/throat) Soy, Nuts, Seeds, Dairy, Egg products, Fish/Shellfish or Wheat. * The presence of acute or chronic oral conditions including: * Herpes Simplex Virus (recent cold sores) * Stomatitis * Oral Lichen Planus * Angular Cheilitis * Candidiasis * Necrotizing Gingival Diseases * Other inflammatory or infectious pathologies * Active dental caries "cavities" * Any other periodontal diagnosis other than 'Healthy Periodontium' or localized gingivitis
Where this trial is running
Halifax, Nova Scotia
- Dalhousie University — Halifax, Nova Scotia, Canada (Recruiting)
Study contacts
- Principal investigator: Leigha Rock, PhD — Dalhousie University
- Study coordinator: Jacob P Smith, DDS
- Email: jacob.smith@dal.ca
- Phone: 9024836581
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.