Effects of a multi-domain exercise program on memory in adults
Effects of Multi-Domain Exercise Intervention on Memory Performance in Healthy Adults With and Without ApoE e4 Allele: A fMRI Study
This study is testing whether a special exercise program that includes fitness, meditation, and social activities can improve memory in healthy adults aged 45-70.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 45 Years to 70 Years |
| Sex | All |
| Sponsor | National Taiwan Normal University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Taipei City and 1 other locations) |
| Trial ID | NCT05068271 on ClinicalTrials.gov |
What this trial studies
This project is a single-blinded, double-arm, 6-month randomized controlled trial that investigates how a multi-domain exercise program, which includes various physical fitness components, meditation, and social interaction, impacts memory performance and brain activity in cognitively intact adults aged 45-70. The study also explores the role of apolipoprotein epsilon-4 (ApoE e4) status and brain-derived neurotrophic factor (BDNF) as potential moderators and mediators of these effects. Participants will be compared against a control group to assess the effectiveness of the intervention on cognitive functions.
Who should consider this trial
Good fit: Ideal candidates are cognitively intact adults aged 45-70 who can engage in moderate-intensity exercise and meet specific health criteria.
Not a fit: Patients with diagnosed cognitive impairments, major psychiatric illnesses, or significant physical health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance memory performance and cognitive health in aging adults, potentially delaying cognitive decline.
How similar studies have performed: While there is growing evidence supporting the benefits of exercise on cognitive function, studies specifically examining multi-domain exercise programs in this demographic are limited, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Normal or corrected-to-normal vision * Able to speak and read Chinese * Scores of Mini-Mental Status Examination \>= 25 * Physical Activity Readiness Questionnaire score \< 0 * Able to conduct the exercise with moderate intensity * Meet the criteria to undergo magnetic resonance imaging * Provide informed consent Exclusion Criteria: * Diagnosed or self-reported cognitive problems (e.g., mild cognitive impairment or dementia) * Diagnosed or self-reported physical disease (e.g., untreated hypertension and chronic heart disease, stroke, brain tumor, musculoskeletal disorders, other exercise contradictions) * Diagnosed or self-reported major psychiatric illness (e.g., major depression, schizophrenia) * Diagnosed or self-reported neurodegenerative disease (e.g., Alzheimer's disease and other dementias, Parkinson's disease (PD) and PD-related disorders, Huntington's disease) * History of alcohol or drug abuse * History of chemotherapy * Traveling consecutively for three weeks or more during the study * Unwillingness to be randomized to one of the two groups * Currently participating in another study trial Exclusion Criteria for functional magnetic resonance images (fMRI): Participants will be excluded if s/he has a contraindication to fMRI scanning, such as aneurysm clip, implanted neural stimulator, cochlear implant, any implanted device, cardiac pacemaker. To ensure volunteers are eligible for the current project, they will be asked to fill out a questionnaire to inform whether they have conditions (e.g. paralyzed hemidiaphragm) or present unnecessary risks (e.g., pregnancy) during the recruitment period.
Where this trial is running
Taipei City and 1 other locations
- National Taiwan Normal University — Taipei City, Taiwan (Recruiting)
- Yu-Kai Chang — Taipei, Taiwan (Not_yet_recruiting)
Study contacts
- Principal investigator: Yu-Kai Chang, PhD — Department of Physical Education and Sport Sciences, National Taiwan Normal University
- Study coordinator: Yu-Kai Chang, PhD
- Email: yukaichangnew@gmail.com
- Phone: +886277493220
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.