Effects of a ketone supplement on immune cell function
Official title: The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation
Run by University of British Columbia · NCT06590623 · Data updated 2026-11-12
This study is testing whether taking a ketone supplement can change how immune cells work in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 12 (estimated) |
| Sponsor | University of British Columbia Academic / other |
| Locations | 1 site (Kelowna, British Columbia) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | June 1, 2025 |
| Study ends | June 1, 2025 |
| Registry record updated | March 7, 2025 |
| Trial ID | NCT06590623 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults over the age of 19 who can fast overnight.
✕Probably not a fit
Patients who are competitive endurance athletes, follow a ketogenic diet, or have chronic metabolic disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how acute ingestion of an exogenous ketone monoester supplement affects the function of immune cells and their histone β-hydroxybutyrylation in healthy adults. It is a single-arm pilot study focusing on the biochemical changes in monocytes and lymphocytes following ketone supplementation. Participants will be required to fast overnight before the intervention to assess the immediate effects of the supplement on immune response.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of how ketone supplementation influences immune function, potentially leading to new therapeutic strategies.
How similar studies have gone: While the specific effects of exogenous ketones on immune function are still being explored, related studies have shown promising results in metabolic and immune responses.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Over the age of 19 * Able to fast overnight Exclusion Criteria: * Being a competitive endurance athlete. * Following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements. * Being unable to travel to and from the university * Being pregnant. * Having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease * Being unable to read or communicate in English.
Where it's running
-
University of British Columbia Okanagan Campus
Kelowna, British Columbia, Canada Recruiting
Study contacts
- Study coordinator: Jonathan Little Principal Investigator, Professor Little, Ph.D
- Email: jonathan.little@ubc.ca
- Phone: 250-807-9876
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.