Effectiveness of medications for gastrointestinal erosions and ulcers
RCT Using Bonopurazan or Esomeprazole in Patients With NSAIDs-induced Erosions and/or Ulcers
This study is testing two medications, Bonoprazan and Esomeprazole, to see which one helps people with stomach erosions or ulcers caused by long-term use of pain relievers.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 124 (estimated) |
| Ages | 20 Years to 99 Years |
| Sex | All |
| Sponsor | Shinshu University Academic / other |
| Locations | 1 site (Matsumoto, Nagano) |
| Trial ID | NCT03315676 on ClinicalTrials.gov |
What this trial studies
This study evaluates the clinical efficacy and safety of two medications, Bonoprazan and Esomeprazole, in patients who have experienced gastrointestinal erosions or ulcers due to long-term NSAID use. Participants will be monitored for their gastrointestinal symptoms after taking these medications for a specified duration. The goal is to determine which medication provides better relief and healing for these conditions. The study focuses on patients who have a history of gastrointestinal issues related to NSAID consumption.
Who should consider this trial
Good fit: Ideal candidates are individuals with a clinical diagnosis of NSAIDs-induced gastrointestinal erosions or ulcers who are seeking treatment with Bonoprazan or Esomeprazole.
Not a fit: Patients who are allergic to Bonoprazan or Esomeprazole will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide effective treatment options for patients suffering from NSAID-induced gastrointestinal erosions and ulcers.
How similar studies have performed: While there have been studies on proton pump inhibitors, the specific combination and focus on Bonoprazan in this context may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of NSAIDs-induced gastrointestinal Erosions and/or Ulcers who want to take Bonoprazan or Esomeprazole Exclusion Criteria: * Patients allergic to Bonoprazan or Esomeprazole
Where this trial is running
Matsumoto, Nagano
- Yukio Nakamura — Matsumoto, Nagano, Japan (Recruiting)
Study contacts
- Study coordinator: Yukio Nakamura, MD, PhD
- Email: yxn14@aol.jp
- Phone: +81-263-37-2659
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.