Effect of Tamsulosin on urinary retention after pelvic surgery
Official title: The Impact of Tamsulosin on Duration of Post-Operative Urinary Retention in Women Undergoing Pelvic Reconstructive Surgery- A Double Blind, Randomized, Placebo-Controlled Study
Run by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · NCT04597372 · Data updated 2026-11-12
This study is testing if Tamsulosin can help women who have urinary retention after pelvic surgery get better faster than those who receive a placebo.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 154 (estimated) |
| Sponsor | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | November 3, 2021 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | March 20, 2026 |
| Trial ID | NCT04597372 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 and older who experience postoperative urinary retention after pelvic reconstructive surgery.
✕Probably not a fit
Patients with a history of urinary retention prior to surgery or those with severe comorbid conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of Tamsulosin in reducing the duration of acute postoperative urinary retention (POUR) in women following pelvic reconstructive surgery. It is a double-blind, randomized, placebo-controlled trial where participants will receive either Tamsulosin or a placebo after being diagnosed with POUR. The primary outcome will be the duration of catheterization, measured in days, and secondary outcomes include the incidence of urinary tract infections and quality of life assessments using the Euroqol-5D (EQ-5D) scale. The study will involve women aged 18 and older who consent to participate and meet specific eligibility criteria.
Why it matters
Potential benefit: If successful, this study could lead to improved management of urinary retention post-surgery, enhancing recovery and quality of life for patients.
How similar studies have gone: Other studies have shown promising results with Tamsulosin in similar contexts, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older * willing and able to provide informed consent * postoperative urinary retention as defined by a failed RGVT prior to hospital discharge * Ability to speak and read English * Tolerate pill ingestion Exclusion Criteria: * allergy/intolerance to Tamsulosin or sulfa drugs * preoperative history of urinary retention as defined by preoperative post void residual of \>150mL * current use of alpha antagonist medication for hypertension * severe dementia * end stage renal or liver disease * history of severe heart failure or major cardiovascular event in the last 6 months
Where it's running
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West Penn Hospital
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Lindsay Turner, MD — Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
- Study coordinator: Lindsay Turner
- Email: lindsay.turner@AHN.ORG
- Phone: (412)-330-4567
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Rectus Abdominis Detrusor Myoplasty for Urinary Retention
A surgical approach using a patient’s abdominal muscles is being tested to help the bladder squeeze and empty urine in people with urinary retention.
-
Tamsulosin to prevent and shorten postoperative urinary retention after spine surgery
This trial will test whether taking tamsulosin around the time of spine surgery can reduce how often patients have urinary retention and how long it lasts.
-
Intrathecal morphine and urinary retention after revision knee replacement
This study will see if adding a small dose of spinal (intrathecal) morphine for adults having revision knee replacement lowers early pain but raises the chance of needing a urinary catheter.
-
Electroacupuncture for Postoperative Urinary Retention After Cervical Cancer Surgery
This trial tests whether electroacupuncture can help people with POUR after radical hysterectomy for cervical cancer, compared with a sham treatment.
-
Transcutaneous electrical acupoint stimulation for postoperative urinary retention after radical hysterectomy for cervical cancer
We will try transcutaneous electrical acupoint stimulation (TEAS) versus a sham TEAS to help people who cannot fully empty their bladder after radical hysterectomy for cervical cancer.
-
Impact of Tamsulosin on Urinary Retention After Urogynecology Surgery
This study tests if giving tamsulosin before pelvic surgery can help patients avoid needing a catheter after their operation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.