Effect of taking blood pressure medications in the morning versus at bedtime
Chronotherapy in Hypertension - a Study of Blood Pressure Levels Following Intake of Antihypertensive Medication in the Morning or at Bedtime
This study is testing if taking blood pressure medications in the morning or at bedtime helps people aged 40-75 manage their blood pressure and overall health better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 40 Years to 75 Years |
| Sex | All |
| Sponsor | Vastra Gotaland Region Government |
| Locations | 3 sites (Gothenburg and 2 other locations) |
| Trial ID | NCT05322967 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the impact of the timing of antihypertensive medication intake on blood pressure and related health markers. Participants aged 40-75 years, who have been on stable antihypertensive treatment, will be randomly assigned to take their medications either in the morning or at bedtime. After an 8-week period, the timing will shift for each participant, allowing for a direct comparison of outcomes such as blood pressure, renal function, and cholesterol levels. The study aims to explore whether chronotherapy can enhance the effectiveness of existing antihypertensive treatments.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 40-75 years with a diagnosis of hypertension who are on stable antihypertensive treatment.
Not a fit: Patients with conditions such as atrial fibrillation, diabetes, or previous cardiovascular events may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved blood pressure control and reduced cardiovascular risks for patients with hypertension.
How similar studies have performed: Previous studies have shown promising results with similar chronotherapy approaches in managing hypertension.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of hypertension * Stable antihypertensive treatment at least 8 weeks prior to inclusion * One to four antihypertensive drugs Exclusion Criteria: * Atrial fibrillation/flutter * Diabetes * Previous stroke or TIA * Heart failure * Ischemic heart disease * Peripheral artery disease * Malignant disease with less than one year expected survival * Inability to follow study protocol (for instance shift work)
Where this trial is running
Gothenburg and 2 other locations
- Sahlgrenska University Hospital, Mölndal — Gothenburg, Sweden (Recruiting)
- Närhälsan Billingen Primary Health Care Centre — Skövde, Sweden (Recruiting)
- Närhälsan Norrmalm Primary Health Care Centre — Skövde, Sweden (Not_yet_recruiting)
Study contacts
- Principal investigator: Karin Manhem, Prof, MD — Sahlgrenska University Hospital
- Study coordinator: Kristina B Boström, Prof, MD
- Email: kristina.a.bengtsson@vgregion.se
- Phone: 0702409091
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.