Effect of rTMS on brain factors in cocaine dependence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of 5-Hz repetitive transcranial magnetic stimulation (rTMS) on serum brain-derived neurotrophic factor (BDNF), craving, and cognitive function in individuals with cocaine use disorder. It features a longitudinal design with a short-term double-blind placebo-controlled phase involving 20 rTMS sessions, followed by a long-term phase of maintenance therapy over 12 weeks. Participants will undergo clinical assessments and blood tests at three time points to evaluate changes in BDNF levels, craving, and cognitive performance. The study also includes a comparative group to measure outcomes during periods without cocaine consumption.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Current cocaine use disorder according to the Diagnostic and statistical manual of mental disorders (DSM 5).
2. Cocaine crack or powder use for at least 12 months with a frequency of 3 times or more per week, with abstinence periods shorter than 1 year for the last year.
3. Primary school completed.

Exclusion Criteria:

1. Personal or first degree family history of any neurological disorder including, but not limited to, organic brain syndrome, epilepsy, brain injuries, multiple sclerosis, conditions that increase intracranial pressure.
2. Personal history of brain surgery or traumatic brain injury.
3. Comorbilities that could represent a risk of neuroinfection or increased convulsive threshoid.
4. Other than alcohol, tobacco or marijuana substance use disorder.
5. If the patient does not meet the safety criteria for rTMS.
6. Current use of any medication that might provoque seizures or any anticonvulsant drugs.
7. Personal history of schizophrenia, mania/hypomania or OCD.
8. Personal history of myocardial infarction, angina, congestive heart failure, cerebrovascular events, transient ischemic attack or any other heart condition currently undergoing medical treatment.
9. Personal history of seizures or detection of paroxysmal EEG activity.

Where it's running

• Instituto Nacional de Psiquiatría Ramón de la Fuente M.
  Mexico City, Tlalpan, Mexico Recruiting

Study contacts

• Study coordinator: Erik D. Morelos-Santana, Ph D. Candidate
• Email: emorelos@imp.edu.mx
• Phone: 5255416053503

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Mild electrical brain stimulation (tDCS) with cognitive training to reduce cocaine cravings.

  This trial will test whether brief sessions of mild electrical brain stimulation (tDCS) combined with cognitive reappraisal training can lower craving in adults receiving inpatient treatment for cocaine use disorder.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07318480

• Effects of ketamine and neurofeedback on cocaine addiction

  This study is testing whether combining ketamine with brain training can help people struggling with cocaine addiction reduce their use and improve their brain function.

  Recruiting Phase 2 Psychiatric University Hospital, Zurich · Zurich, Canton of Zurich · NCT06125054

• rTMS plus cognitive-behavioral therapy for cocaine use disorder

  This study tests whether adding rapid magnetic brain stimulation to standard CBT helps people with cocaine use disorder reduce use and improve brain connectivity.

  Recruiting New York State Psychiatric Institute · New York, New York · NCT05974202

• Vaccine to prevent cocaine effects in dependent individuals

  This study is testing a new vaccine that aims to help people with cocaine dependence by blocking the drug's effects on the brain.

  Recruiting Phase 1 Weill Medical College of Cornell University · New York, New York · NCT02455479

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.