Effect of Reboxetine and Methylphenidate on Attention and Emotion in PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of reboxetine and methylphenidate on attentional, sensory, and emotional dysregulation in adults diagnosed with Posttraumatic Stress Disorder (PTSD). It aims to characterize the relationship between attention deficits and PTSD symptoms through a case-control design involving 53 patients with PTSD and 53 matched healthy controls. Participants will undergo baseline assessments before being randomized into either an active treatment group or a placebo group in a double-blind manner. The study seeks to explore how these medications may improve attention and emotional regulation in individuals suffering from PTSD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosed with PTSD according to DSM-IV or DSM-5 criteria
* current treatment at the outpatient facilities of Lev HaSharon Netanya Adult Clin
* age between 20 and 60 years
* PTSD diagnosis at least one month prior to study inclusion
* no present-day re-exposure to the traumatic event
* any psychotropic drug therapy that is being administered must be at a fixed dose for at least one month prior to the study conductance

Exclusion Criteria:

1. comorbid major psychiatric disorder, e.g. psychotic disorder, unipolar or bipolar disorder, borderline personality disorder, or active suicidal ideation,
2. ADHD diagnosis,
3. significant or severe systematic disease that limits normal activity, e.g. autoimmune disease, AIDS or renal failure,
4. cardiovascular disease, e.g. hypertension, atrioventricular (AV) block, bradycardia, or conduction disorder,
5. severe disease that is a threat to life, e.g. acute myocardial infarction, respiratory failure, or cancer,
6. nervous system impairment, e.g. multiple sclerosis, Alzheimer's disease, Parkinson's disease, epilepsy, or stroke,
7. previous or current severe traumatic brain injury,
8. glaucoma,
9. impaired hearing,
10. pregnancy or breastfeeding during study inclusion,
11. active substance dependency including regular use of medical cannabis,
12. use of steroid medication in the two months prior to study conductance,
13. use of medication that may affect the function of the central nervous system,
14. failure to complete all research steps

Where it's running

• Emek Medical Center
  Afula, Israel Recruiting
• University of Haifa
  Haifa, Israel Recruiting
• Lev HaSharon Mental Health Center
  Netanya, Israel Recruiting

Study contacts

• Principal investigator: Avi Avital, PhD — University of Haifa
• Study coordinator: Avi Avital, PhD
• Email: avitalavi@hotmail.com
• Phone: +972-4-8420-364

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.