Effect of Platelet-rich Fibrin and Vitamin D3 Injections on Tooth Movement
The Effect of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Canine Retraction: A Randomized Controlled Clinical Trial
This study tests whether injections of platelet-rich fibrin or vitamin D3 can speed up tooth movement during orthodontic treatment for people getting braces.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Beni-Suef University Academic / other |
| Locations | 1 site (Banī Suwayf, Beni Suef Governorate) |
| Trial ID | NCT06071455 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate and compare the effects of platelet-rich fibrin (PRF) and vitamin D3 injections on the rate of canine retraction in orthodontic treatment. Participants will be randomly assigned to two groups, with one receiving PRF injections and the other receiving vitamin D3 injections, each on one side of the mouth while the contralateral side serves as a control. The study will also assess changes in bone thickness associated with each technique. A total of 28 cases will be recruited from the Faculty of Dentistry at Beni-Suef University, and randomization will be conducted using a computer-generated schedule.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 18-40 with Class I or Class II dental malocclusion requiring upper canine retraction.
Not a fit: Patients with active periodontal disease, poor oral hygiene, systemic diseases affecting bone metabolism, or craniofacial anomalies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the efficiency of orthodontic treatments by accelerating tooth movement.
How similar studies have performed: While there is limited data on the specific combination of PRF and vitamin D3 for this purpose, similar studies have shown promising results with PRF in enhancing tooth movement.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: 18- 40 years old. 2. Angle Class I or Class II dental malocclusion that required bilateral maxillary first premolar extraction and upper canine retraction as a part of the treatment plan. 3. Good to fair oral hygiene. 4. Normal probing depth. Exclusion Criteria: 1. Active periodontal disease. 2. Poor oral hygiene. 3. Systemic diseases or medications that alter bone metabolism or tooth movement. 4. Craniofacial anomalies.
Where this trial is running
Banī Suwayf, Beni Suef Governorate
- Faculty of Dentistry Beni Suef University — Banī Suwayf, Beni Suef Governorate, Egypt (Recruiting)
Study contacts
- Principal investigator: Rehab Khalil — Faculty of Dentistry, Beni Suef University
- Study coordinator: Rehab Khalil
- Email: rehababdelrazek@dent.bsu.edu.eg
- Phone: 01005230669
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.