Effect of PEEP on gastric volume during anesthesia in children
Effect of Positive End Expiratory Pressure on Gastric Insufflation During Face Mask Induction of General Anesthesia in Children Undergoing Elective Surgery: A Prospective Randomized Controlled Study
This study is testing how different levels of breathing support during anesthesia affect stomach size in children having surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 1 Year to 12 Years |
| Sex | All |
| Sponsor | Kasr El Aini Hospital Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06127173 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate how different levels of Positive End Expiratory Pressure (PEEP) affect gastric volume in children undergoing elective surgery with general anesthesia. Participants will be randomly assigned to one of three groups receiving varying PEEP levels: 0 cmH2O, 3 cmH2O, or 5 cmH2O. The gastric volume will be assessed using ultrasound before the induction of anesthesia. The study will ensure blinding for parents and sonographers to minimize bias in the results.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 1 to 12 years with ASA physical status I or II scheduled for elective surgery under general anesthesia.
Not a fit: Patients who may not benefit from this study include those with increased risk of regurgitation, known respiratory diseases, or uncorrected congenital heart disease.
Why it matters
Potential benefit: If successful, this study could improve anesthesia safety by reducing the risk of gastric insufflation during procedures in children.
How similar studies have performed: While the specific approach of using PEEP levels in this context may be novel, similar studies have explored the effects of PEEP on respiratory mechanics and gastric volume, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Children aged1 to 12 years old American Society of Anesthesiologists (ASA) physical status I or II Children will be scheduled for elective surgery under general anesthesia. Exclusion Criteria: Parental refusal Children with increased risk of regurgitation Known respiratory diseases or uncorrected congenital heart disease
Where this trial is running
Cairo
- Cairo university hospitals, kasralainy — Cairo, Egypt (Recruiting)
Study contacts
- Principal investigator: Khaled Sarhan, MD — Cairo University Hospitals
- Study coordinator: Khaled Sarhan, MD
- Email: khaled.sarhan@kasralainy.edu.eg
- Phone: +201020067816
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.