Effect of Neurodynamic Intervention on Chronic Ankle Instability

The Effect of Additional Neurodynamic Intervention in Patients With Chronic Ankle Instability

Not applicable Interventional National Yang Ming Chiao Tung University · NCT05090423

This study tests whether adding a special nerve treatment to balance training can help people with chronic ankle instability feel better and improve their balance.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment40 (estimated)
Ages20 Years to 50 Years
SexAll
SponsorNational Yang Ming Chiao Tung University Academic / other
Locations1 site (Taipei)
Trial IDNCT05090423 on ClinicalTrials.gov

What this trial studies

This study investigates the impact of additional neurodynamic intervention on patients suffering from chronic ankle instability (CAI). It aims to compare two groups: one receiving only balance training and the other receiving both balance training and neurodynamic intervention targeting the common peroneal nerve. The study will assess outcomes such as ankle range of motion, mechanosensitivity, balance performance, and self-reported function. A total of 40 patients with a history of multiple ankle sprains will be recruited for this intervention.

Who should consider this trial

Good fit: Ideal candidates are individuals with a history of at least two ankle sprains in the same leg and significant instability as measured by the Cumberland Ankle Instability Tool.

Not a fit: Patients with recent surgical treatments, fractures, or significant pain in the lumbar or cervical spine may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could improve mobility and reduce pain for patients with chronic ankle instability.

How similar studies have performed: While the effects of neurodynamic interventions are still unclear, previous studies have indicated potential benefits in addressing mechanosensitivity in similar conditions.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. History of at least two ankle sprains in the same leg, of which the first sprain is more than one year
2. Leading to at least one interrupted day of desired physical activity
3. The Cumberland Ankle Instability Tool (CAIT) ≦ 24
4. Slump test in ankle plantar flexion with inversion: positive

Exclusion Criteria:

1. Pregnancy
2. Surgical treatments
3. Previous fractures in either lower extremity
4. Any concomitant lower extremity pathology, for example, vascular disease, osteoarthritis and rheumatoid arthritis
5. Significant pain or injury to the lumbar or cervical spine
6. Regular use of medication: anti-inflammatory drugs, painkiller, steroid or muscle relaxants
7. Previous manual therapy or exercise interventions received on the lower extremity within the previous 3 months

Where this trial is running

Taipei

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Ankle SprainsChronic ankle instabilityNeurodynamicsMechanosensitivity
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.