Effect of magnesium sulfate on muscle relaxation during surgery
Effect of Magnesium Sulphate Pretreatment on Cis-Atracurium Induced Neuromuscular Block and Recovery Characteristics: A Randomized Controlled Trial.
This study is testing if magnesium sulfate can improve muscle relaxation during surgery for patients by working better with a common anesthetic.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut, Asyut Governorate) |
| Trial ID | NCT05757999 on ClinicalTrials.gov |
What this trial studies
This study evaluates how magnesium sulfate affects the onset and duration of muscle relaxation induced by cis-atracurium in patients undergoing elective otorhinolaryngological surgery. Participants will be divided into two groups: one receiving magnesium sulfate and the other receiving saline as a comparator. The study aims to assess the impact of magnesium sulfate on neuromuscular blockade and the period of no response to nerve stimulation. By exploring this approach, the study seeks to enhance the efficacy of anesthesia while minimizing the required doses of other anesthetic agents.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-60 scheduled for elective otorhinolaryngological surgery with a BMI between 18.5 and 24.9.
Not a fit: Patients with neuro-muscular diseases, renal or hepatic impairment, or those outside the specified age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved muscle relaxation during surgery, potentially enhancing patient safety and comfort.
How similar studies have performed: Previous studies have shown that magnesium sulfate can enhance the effects of neuromuscular blocking agents, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age group 18-60 years old * Both genders * Patients who will be scheduled to undergo elective otorhinolaryngological surgery. * Patients with BMI between 18.5 and 24.9 Kg/m2. * Patients with American Society of Anesthesiologist physical status classification of 1 or 2 Exclusion Criteria: * Patients who are less than 18 years old or more than 60 years old. * Patients on medications that interfered with muscle activity. * Allergy to medications used in this study. * Pregnancy or suspected pregnancy. * Neuro-muscular diseases. * Renal or hepatic impairment. * Hypermagnesemia (\>2.5 mmol) or hypomagnesemia (\<1.7 mmol). * Patients refusing to study
Where this trial is running
Asyut, Asyut Governorate
- Assiut university main hospital, ENT operative theatre — Asyut, Asyut Governorate, Egypt (Recruiting)
Study contacts
- Principal investigator: Hala Abdel-Ghaffar, MD — Professor of anesthesia and intensive care, faculty of medicine, Assiut university, Assiut, Egypt.
- Study coordinator: Hala S Abdel-Ghaffar, MD
- Email: hallasaad@yahoo.com
- Phone: 01003812011
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.