Effect of Lupatadine Fumarate on Allergic Rhinitis
Official title: Study on the Effect and Mechanism of Lupatadine Fumarate in the Treatment of Allergic Rhinitis
Run by The First Affiliated Hospital with Nanjing Medical University · NCT06709092 · Data updated 2026-11-12
This study is testing if Lupatadine Fumarate can help adults with allergic rhinitis feel better by reducing their symptoms like nasal congestion.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Locations | 2 sites (Nanjing, Jiangsu and 1 other locations) |
| Status | Recruiting |
| Started | March 1, 2024 |
| Main results expected | December 2024 |
| Study ends | December 2026 |
| Registry record updated | November 29, 2024 |
| Trial ID | NCT06709092 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18-65 who have been diagnosed with allergic rhinitis and have positive dust mite sensitization tests.
✕Probably not a fit
Patients with recent use of certain medications, nasal diseases, or severe comorbid conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness and underlying mechanisms of Lupatadine Fumarate in treating allergic rhinitis, a condition affecting a significant portion of the population in China. The research aims to explore how this medication, which has both antihistamine and platelet-activating factor antagonistic properties, alleviates symptoms such as nasal congestion. The study will include adult patients diagnosed with allergic rhinitis based on clinical history and specific sensitization tests. By examining the role of tight junction proteins and inflammatory pathways, the study seeks to provide insights into new therapeutic targets for this common allergy.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for patients suffering from allergic rhinitis.
How similar studies have gone: While the specific approach of using Lupatadine Fumarate is being explored in this study, similar antihistamine treatments have shown promise in managing allergic rhinitis in previous research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (18-65 years). * Patients with allergic rhinitis were diagnosed based on clinical history and positive dust mite sensitization tests (skin prick test and/or specific IgE). Exclusion Criteria: * Received glucocorticoids, immunomodulatory, antihistamine drugs, and other medications that may affect the study results within the last 1 month. * Nasal diseases such as upper respiratory tract infections, chronic sinusitis with or without nasal polyps, and nasal sinus tumors. * History of nasal sinus surgery. * With other immune and allergic diseases. * Patients with a combination of severe cardiac, cerebrovascular or pulmonary - diseases, aspirin triad, primary ciliary dyskinesia, immune deficiency, and coagulation disorders. * Pregnant women. * Smokers.
Where it's running
-
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China Recruiting -
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China Not yet recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.