Effect of increased water intake on muscle health in older adults in care facilities
Efficacy of a Water Intervention in the Improvement of Anabolic Resistance and Some Physiologic Adaptive Water Conservation Mechanisms in Institutionalized Aged Population. A Randomized Controlled Trial.
This study is testing if drinking more water can help older adults in care facilities keep their muscles healthy and prevent muscle loss.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Consorci Sanitari del Maresme Academic / other |
| Locations | 1 site (Mataró, Barcelona) |
| Trial ID | NCT06497426 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the impact of a supervised water intervention on anabolic resistance and physiological responses in institutionalized individuals aged 65 and older. Participants will be randomly assigned to either a water ingestion regimen of 30-35 ml/kg/day for seven days or to a control group receiving usual care. The study will measure various outcomes related to muscle health, including nitrogen balance and urea excretion, to assess the effectiveness of the intervention in combating muscle loss associated with aging.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 65 and older who are living in nursing homes or convalescence units.
Not a fit: Patients with acute infections, severe chronic diseases, or advanced dementia may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could improve muscle health and overall physical function in older adults, potentially reducing frailty and dependency.
How similar studies have performed: While the specific approach of this study may be novel, previous research has indicated that hydration can play a role in muscle health among older adults.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * subjects ≥65 years, * institutionalized in a nursing home or in a convalescence unit in a socio sanitary center, * who give their informed consent. Exclusion Criteria: * acute infectious disease, * exacerbation of a chronic inflammatory disease * less than 3 weeks from surgery, * hepatic cirrhosis, * chronic renal failure (with glomerular filtrate \<40), * decompensate heart failure with edema in lower-limbs or acute pulmonary edema, * active neoplasia, * in palliative care or life expectancy less than 6 months, * advanced dementia (GDS\>5), * dysphagia, * carrier of bilateral hip or knee prostheses, heart pacemaker * serum therapy, * Users of parenteral nutrition or nasogastric tube nutrition, and * users of diapers (if they are not regular urinary tract carriers).
Where this trial is running
Mataró, Barcelona
- Consorci Sanitari del Maresme — Mataró, Barcelona, Spain (Recruiting)
Study contacts
- Study coordinator: Mateu Serra-Prat, MD PhD
- Email: mserra@csdm.cat
- Phone: +34937417700
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.