Effect of High Definition Transcranial Direct Current Stimulation on Anxiety Disorder
Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Anxiety Disorder
This study is testing whether a new brain stimulation treatment can help people with anxiety feel better by looking at their symptoms and brain activity.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Anhui Medical University Academic / other |
| Locations | 1 site (Hefei) |
| Trial ID | NCT05298007 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of high definition transcranial direct current stimulation (HD-tDCS) on anxiety symptoms and associated somatic symptoms in patients diagnosed with anxiety disorder. A total of 60 participants, aged 18 to 60, will be randomly assigned to receive either active or sham HD-tDCS treatment over 14 sessions. The study will also utilize functional magnetic resonance imaging (fMRI) to explore the underlying neural mechanisms of the intervention. Participants will undergo clinical evaluations and laboratory examinations before and after the treatment to assess the efficacy of the intervention.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 60 diagnosed with anxiety disorder according to DSM-5 criteria.
Not a fit: Patients with severe somatic diseases, other neurological or mental disorders, or those who cannot undergo MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could provide a novel non-invasive treatment option for patients suffering from anxiety disorders.
How similar studies have performed: Other studies have shown promising results with transcranial direct current stimulation for various mental health conditions, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of DSM-5 for anxiety, and HAMA\>14, PHQ-15\>5. * the age ranged from 18 to 60 years old, and the length of education was more than 5 years. * the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests. Exclusion Criteria: * accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on. * accompanied by other neurological diseases, such as stroke, epilepsy and so on. * pregnant and lactating women. * accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective disorder, hysteria, autism and so on. * patients with MRI taboos or factors affecting imaging quality, such as cardiac pacemaker, cochlear implant, cardio-cerebrovascular metal stent, metal denture, etc. * those who could not cooperate with those who completed the relevant experiments, such as patients with depressive stupor, claustrophobia and so on.
Where this trial is running
Hefei
- Anhui Medical University — Hefei, China (Recruiting)
Study contacts
- Study coordinator: Kai Wang, PhD
- Email: wangkai1964@126.com
- Phone: +86-0551-62923704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.