Effect of extraction-space closure timing on gingival cleft formation during canine movement
Official title: Gingival Cleft Development at Two Time Points of Canine Retraction: a Split-mouth Randomized Controlled Trial
Run by Bahria University · NCT07210762 · Data updated 2026-11-12
This test will see if starting space closure early versus waiting changes how often gingival clefts form in orthodontic patients after premolar extractions.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 19 (estimated) |
| Sponsor | Bahria University Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Status | Recruiting |
| Started | October 15, 2025 |
| Main results expected | March 19, 2026 |
| Study ends | July 19, 2026 |
| Registry record updated | October 7, 2025 |
| Trial ID | NCT07210762 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are orthodontic patients requiring extraction of both first premolars with full permanent dentition (except third molars), good periodontal health, non-smokers, and no systemic conditions affecting bone remodeling.
✕Probably not a fit
Patients with periodontitis, poor periodontal health, smokers, those with systemic diseases affecting bone remodeling, or prior periodontal surgery in the area are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a split-mouth randomized controlled trial where quadrants are allocated to early versus delayed initiation of canine retraction after premolar extraction. Each participant will have one side treated early and the opposite side treated later, and gingival cleft development will be recorded at two time points. The main outcome is the incidence of gingival cleft formation associated with the timing of space closure. The single-center trial will enroll patients who need extraction of both first premolars and meet periodontal and systemic health criteria.
Why it matters
Potential benefit: If successful, choosing the optimal timing for space closure could reduce gingival clefts and improve gum health and appearance after orthodontic extractions.
How similar studies have gone: Existing literature on timing of space closure and gingival clefts is limited and findings are mixed, so this approach is relatively novel in its specific focus.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Extraction advised of both first premolars from either maxilla, mandible or both. 2. All permanent dentition present apart from third molars. Exclusion Criteria: 1. Severe crowding 2. Smokers 3. Patients with systemic diseases that could interfere with bone remodeling. 4. Patients with periodontitis or poor periodontal health. 5. Patients who have previously undergone periodontal surgery in the area of interest. 6. Patients with other oral health conditions that could complicate the treatment or healing process.
Where it's running
-
Bahria University of Health Sciences Karachi
Karachi, Sindh, Pakistan Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.