Effect of Exercise on Immune Response to COVID-19 Vaccination
The Effect of Health Behavioral Variables Including Single Session Exercise Post-immunization and Psychosocial Factors on Immune Response to the Initial COVID-19 mRNA Vaccine, and Underlying Mechanisms
This study is testing whether doing light to moderate exercise right after getting the first dose of a COVID-19 vaccine can help boost the immune response to the vaccine.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Sponsor | Iowa State University Academic / other |
| Locations | 1 site (Ames, Iowa) |
| Trial ID | NCT05213000 on ClinicalTrials.gov |
What this trial studies
This study evaluates how a single session of light to moderate intensity exercise performed shortly after receiving the initial dose of a COVID-19 mRNA vaccine affects the immune response to the vaccination. Participants will be randomly assigned to either an exercise group, where they will engage in a 90-minute supervised exercise session, or a control group with no exercise. Blood samples will be collected at various intervals to analyze immune response and psychosocial factors related to stress and resilience will also be assessed through surveys. The goal is to identify potential mechanisms that may enhance vaccine efficacy through exercise.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-64 who regularly exercise and are planning to receive their initial COVID-19 mRNA vaccine.
Not a fit: Patients who are pregnant, weigh less than 110 pounds, or have conditions that impair their ability to exercise or respond to the vaccine may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the immune response to COVID-19 vaccination, potentially leading to better protection against the virus.
How similar studies have performed: While the specific approach of this study is novel, previous research has suggested that exercise can positively influence immune responses, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to donate a small amount of blood, * Planning to receive an initial mRNA Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine, * Between 18-64 years of age, * Regularly participate in some form of exercise two or more times per week, including at least one session equal to or greater than 50 minutes exercise sessions or walk three or more times per week with at least one session equal to or greater than 50 minutes. * Can safely perform 90 minutes of light to moderate intensity exercise (walk, walk/jog, or jog) based on American College of Sports Medicine exercise participation guidelines Exclusion Criteria: * Currently pregnant * Weigh less than 110 pounds. * Presence of any conditions that could significantly impact the ability to exercise safely, or unable to receive the mRNA COVID-19 vaccine * Taking medication that significantly impact immune response or the presence of an immune disorder.
Where this trial is running
Ames, Iowa
- Iowa State University — Ames, Iowa, United States (Recruiting)
Study contacts
- Study coordinator: Marian Kohut, PhD
- Email: mkohut@iastate.edu
- Phone: 5152948364
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.