Effect of Endometrial Compaction on Pregnancy Rates in Frozen Embryo Transfers
Impact of Endometrial Compaction on Clinical Pregnancy Rate in Frozen Embryo Transfers
This study is trying to see if how much the lining of the uterus gets thicker before a frozen embryo transfer can help women aged 20-35 have a better chance of getting pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 20 Years to 35 Years |
| Sex | Female |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06583265 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the correlation between endometrial compaction and clinical pregnancy rates in women undergoing frozen embryo transfer (FET) cycles. Specifically, it will assess changes in endometrial thickness from the estrogen-only phase to the day of embryo transfer, hypothesizing that greater compaction indicates better endometrial receptivity. The study will focus on women aged 20-35 years who are undergoing down-regulated FET with Day 5 embryos. By analyzing these relationships, the study seeks to enhance understanding of factors influencing successful pregnancy outcomes in IVF.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 20-35 years undergoing down-regulated frozen embryo transfer cycles.
Not a fit: Patients with chromosomal abnormalities, uterine malformations, recurrent implantation failures, or persistent low endometrial thickness may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that improve pregnancy rates in women undergoing frozen embryo transfers.
How similar studies have performed: While the specific approach of measuring endometrial compaction is novel, similar studies have explored endometrial receptivity and its impact on IVF outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women undergoing down regulated cycles frozen embryo transfer. * Women at age group 20-35 years old. * Day 5 embryos will be transferred. Exclusion Criteria: * Chromosomal abnormality in either partner (As this could lead to cycle cancellation). * Uterine malformation or any intrauterine condition affecting the pregnancy outcomes of FET, such as endometrial polyps, uterine cavity adhesion, history of endometrial tuberculosis, hydrosalpinx with a reflux into uterine cavity (As the might not be candidates for IVF cycle till correction). * Recurrent implantation failure, defined as 2 or more previous failed trials (Other confounding factors might of present which could affect the results). * Cycles of patients with persistent endometrial thickness \<7mm during treatment protocol (Due to cycled cancelation).
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.