Effect of Endometrial Compaction on Pregnancy Rates After Embryo Transfer
Impact of Endometrial Compaction on Reproductive Outcomes After Cryotransfer of Euploid Embryos in a Natural Cycle: Prospective Cohort Study
This study is trying to see if women with endometrial compaction have different pregnancy rates after transferring healthy embryos compared to those with stable or thicker endometrial lining.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 206 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Female |
| Sponsor | Instituto Bernabeu Academic / other |
| Locations | 1 site (Madrid) |
| Trial ID | NCT05960370 on ClinicalTrials.gov |
What this trial studies
This multicenter prospective observational cohort study aims to compare ongoing pregnancy rates in natural cycles for euploid embryo transfer between two groups of women: those who experience endometrial compaction and those with stable or increased endometrial thickness. The study will include 206 women aged 18 to 50 with primary or secondary infertility, who will undergo endometrial preparation for the transfer of genetically normal embryos. The main objective is to determine how endometrial compaction affects reproductive outcomes, with an estimated duration of 24-30 months for the study.
Who should consider this trial
Good fit: Ideal candidates are women aged 18 to 50 with primary or secondary infertility who are preparing for the transfer of euploid embryos.
Not a fit: Patients with uterine or endometrial diseases, a history of recurrent implantation failure, or those unable to accurately assess endometrial thickness may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into optimizing embryo transfer protocols to improve pregnancy rates in women undergoing fertility treatments.
How similar studies have performed: While the specific focus on endometrial compaction is novel, similar studies have explored factors affecting embryo transfer success, indicating potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18 to 50 years * Primary or secondary infertility * Normal uterine cavity * Endometrial preparation in a modified natural cycle for single embryo transfer * Embryo in blastocyst state from own oocyte or oocyte donation cycles, who had normal results on preimplantation genetic testing for aneuploidy (PGT-A) via trophectoderm biopsy. Exclusion Criteria: * Uterine or endometrial disease (multiple myomatosis \[\>3 fibroids of \> 3 cm\], adenomyosis, Asherman syndrome) * Difficulties in correctly measuring endometrial thickness due to a retroverted or tilted uterus * History of recurrent implantation failure (3 or more transferred blastocysts of good quality, from their own oocyte \[\<35 years\] or oocyte donation); recurrent early Pregnancy Loss (the loss of two or more pregnancies before 10 weeks of gestational age. * Suboptimal endometrial response (endometrium \< 6 mm on the day of ovulation triggering).
Where this trial is running
Madrid
- Instituto Bernabeu — Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: Esperanza E de la Torre Pérez, Gynecologist
- Email: espe_delatorre@hotmail.com
- Phone: +34625072082
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.