Effect of early intervention on displaced canine teeth in children
The Effectiveness and Cost-effectiveness of Early Intervention to Correct the Position of a Palatally Displaced Maxillary Permanent Canine: A Multicentre RCT
This study is testing if early orthodontic treatment for kids with misplaced canine teeth can help them avoid surgery compared to those who don’t get any treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 324 (estimated) |
| Ages | 10 Years to 12 Years |
| Sex | All |
| Sponsor | Göteborg University Academic / other |
| Locations | 3 sites (Traben-Trarbach and 2 other locations) |
| Trial ID | NCT06267989 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of early orthodontic intervention for children with palatally displaced canines. It involves a multicenter, parallel 3-group randomized design across orthodontic departments in Sweden, Germany, and the UK. The study will compare outcomes between children who undergo extraction of the primary canine or space opening for the adult tooth versus those who receive no treatment. The primary outcome is the proportion of participants who avoid surgery after 18 months, while secondary outcomes include cost-effectiveness and the impact on surrounding teeth.
Who should consider this trial
Good fit: Ideal candidates are children aged 10-11 years with one or both upper permanent canine teeth that are not palpable or show significant eruption differences.
Not a fit: Patients with buccal displacement of the canines, missing permanent lateral incisors, or severe dental crowding may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could reduce the need for surgical procedures in children with displaced canine teeth.
How similar studies have performed: Previous studies have suggested that early intervention can be effective, but this specific approach is being tested in a novel multicenter format.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * One or both upper permanent canine teeth are not palpable or there is a pronounced difference in the eruption between the left and right side. Dental radiographs will be taken to confirm that the permanent tooth is displaced. Canines in sector 5 are going to be excluded from this trial. Exclusion Criteria: * Buccal displacement of the canine(s), missing permanent lateral incisors; severe upper arch dental crowding (\>2mm in each affected quadrant) or associated pathology.
Where this trial is running
Traben-Trarbach and 2 other locations
- Private practice — Traben-Trarbach, Germany (Not_yet_recruiting)
- Gothenbrug University — Gothenburg, Sweden (Recruiting)
- University of Sheffield — Sheffield, United Kingdom (Not_yet_recruiting)
Study contacts
- Principal investigator: Farhan Bazargani, DDS, PhD — Gothenburg University, Gothenburg, Sweden
- Study coordinator: Farhan Bazargani, DDS, PhD
- Email: farhan.bazargani@gu.se
- Phone: +46707546107
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.