Effect of early antibiotics on patients with out-of-hospital cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate whether not administering antibiotics to out-of-hospital cardiac arrest (OHCA) patients with a very low likelihood of infection is as effective as providing early antibiotic treatment. It will compare 28-day all-cause mortality rates, incidence of proven infections, and lengths of ICU and overall hospital stays between the two groups. The study will involve adults over 18 years old who present to the emergency department after OHCA. Participants will be randomly assigned to receive either no antibiotics or early antibiotic therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ● Adults aged \>18 years, presenting to HGH ED after out-of-hospital cardiac arrest

  * Patients with low likelihood of infection as per the definitions provided above
  * Ability to obtain informed consent from the subjects or their next of kin/family member/legal surrogate in case of incapacitation due to sedation, mechanical ventilation, etc. In case the next of kin is not available, an independent physician who is not a part of the investigative team will complete and sign the checklist as per HMC Policy "RES 11026\_Appendix 6.5". (see section 4.1.3 for details) A member of the investigative team and a witness will also sign this form before the potential subject is enrolled in the study.

Exclusion Criteria:

* Patients who have clear evidence of infection, as defined by criteria for the study.

  * Patients who have received antibiotics within the last 1 week prior to admission.
  * Patients with malignancy, except those who have been cured or in complete remission.
  * Females with known pregnancy.
  * Known immunocompromised states (including HIV/AIDS, transplant recipients on immunosuppressant drugs, long-term \[\> 3 weeks of prednisone \>5mg/day equivalent\] steroid therapy).
  * Patients on immunologic disease modifying agents (commonly known as "biologics")
  * Patients considered "brain-dead" or "vegetative state"
  * Patients transferred from another hospital, long term care facility or institution
  * Neutropenia (total WBC \<1,500/mm3 or absolute neutrophil count of \<1,000/mm3)

Where it's running

• Hamad Medical Corporation
  Doha, Baladiyat ad Dawhah, Qatar Recruiting

Study contacts

• Principal investigator: Adeel A Butt, MBBS, MS — Hamad Medical Corporation
• Study coordinator: Adeel A Butt, MBBS, MS
• Email: aabutt@hamad.qa
• Phone: +97433311228

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Minimal Sedation After Out-of-Hospital Cardiac Arrest

  This study tests whether stopping continuous sedation right after return of circulation is as safe as keeping patients sedated in the early hours after OHCA.

  Recruiting University Medical Centre Ljubljana · Ljubljana · NCT07895771

• Drone delivery of AEDs to bystanders for out-of-hospital cardiac arrest

  This project will test whether drones can deliver AEDs quickly to bystanders helping someone who has a cardiac arrest outside a hospital.

  Recruiting University of Surrey · Guildford, Surrey · NCT07430813

• Pre-hospital wearable cooling after out-of-hospital cardiac arrest

  This pilot test tries a battery-free CarbonCool® cooling vest applied by paramedics to adults who regain a pulse after out-of-hospital cardiac arrest but remain unconscious to see if early cooling is feasible and safe.

  Recruiting Singapore General Hospital · Singapore · NCT07421882

• Early double sequential defibrillation for cardiac arrest outside the hospital

  We test whether using two defibrillators in quick succession after the first failed shock helps adults with out‑of‑hospital cardiac arrest and a shockable rhythm survive more often than continuing standard single shocks.

  Recruiting at 9 sites Phase 2/3 Karolinska Institutet · Amsterdam and 13 other locations · NCT07174986

• Prehospital access to extracorporeal cardiopulmonary resuscitation in Prague

  This study is testing if a special emergency treatment called prehospital extracorporeal cardiopulmonary resuscitation (ECPR) can help people who have a cardiac arrest outside of the hospital survive better and have better brain function compared to those who only get treatment in the hospital.

  Recruiting General University Hospital, Prague · Prague, Czechia · NCT06789978

• Initial double sequential defibrillation for out-of-hospital ventricular fibrillation

  This trial will test whether using two defibrillators to give double sequential shocks first improves survival for adults with out-of-hospital cardiac arrest and a shockable rhythm.

  Recruiting St. Olavs Hospital · Trondheim · NCT06672159

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.