Effect of collagen and vitamin C on jumper's knee
Additional Effect of Collagen/Vitamin C in Exercise Treatment for Patellar Tendinopathy (Jumper's Knee); a Randomized Controlled Trial
This study is testing if taking a collagen and vitamin C supplement can help athletes with jumper's knee feel better and recover faster.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 76 (estimated) |
| Ages | 16 Years to 40 Years |
| Sex | All |
| Sponsor | Gelderse Vallei Hospital Academic / other |
| Locations | 1 site (Ede, Gelderland) |
| Trial ID | NCT05407194 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of oral supplementation of hydrolyzed collagen combined with vitamin C in athletes suffering from patellar tendinopathy (jumper's knee). Participants will receive either the collagen/vitamin C supplement or a placebo in addition to standard care, which includes education, load management, and tendon loading exercises. The primary outcome will be measured using the Victorian Institute of Sports Assessment (VISA-P) score at 12, 24, and 52 weeks. The study aims to determine if the supplementation can improve symptoms and recovery in athletes with this condition.
Who should consider this trial
Good fit: Ideal candidates are athletes aged 16 to 40 with a history of knee pain related to patellar tendinopathy lasting at least 12 weeks.
Not a fit: Patients with inflammatory conditions or those outside the age range of 16 to 40 may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance recovery and performance for athletes suffering from patellar tendinopathy.
How similar studies have performed: Previous studies have indicated positive effects of collagen supplementation on tendon health, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 16 - 40 years old (the chosen age range will minimize chances of other conditions causing anterior knee pain such as osteoarthritis among patients above 40 years and osteochondrotic diseases like Sinding-Larsen-Johansson syndrome and Osgood-Schlatter disease among patients below the age of 16). * History of focal knee pain in patellar tendon or its patellar or tibial insertion in association with training and/or competition. * Current symptom duration of at least 12 weeks. * Sports participation at least once a week for at least one year. * Palpation tenderness to the corresponding painful area on the patellar tendon. * Focal patellar tendon pain during patellar tendon loading with a pain provocation test (single leg decline squat and/or single leg jump squat) * Victorian Institute of Sports Assessment (VISA-P) score \< 80 out of 100 points. * Willingness to take (non-vegetarian) nutritional supplements. Exclusion Criteria: * Known presence of inflammatory joint diseases (e.g. spondylarthropathy, gout or rheumatoid arthritis) or familial hypercholesterolaemia. * Daily use of drugs with a putative effect on the patellar tendon in the preceding year (e.g. fluoroquinolones and statins) * Knee surgery without a full completion of the rehabilitation program in the history of the index knee * Previous patellar tendon rupture of the index knee * Local injection therapy with corticosteroids, other drugs, blood, platelet rich plasma or stem cells in the preceding 12 months * Acute knee injuries, including patellar tendon injuries with an acute onset * Inability to perform the PTLE program * Participation in other concomitant treatment programs * Signs or symptoms of other coexisting knee pathology on physical examination (such as patellofemoral pain syndrome, joint effusion and joint line tenderness) or additional diagnostics when found necessary by the sports physician (Chondral lesion of the patella or trochlea on MRI or prepatellar bursitis on US). * Already using collagen supplementation * Giving blood donation in a period of two months prior to each test day * Being pregnant or wish to become pregnant in the upcoming year * Abuse of hard drugs * An alcohol consumption \>21 units/week (men) or \>14 units/week (women)
Where this trial is running
Ede, Gelderland
- Gelderse Vallei Hospital — Ede, Gelderland, Netherlands (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.