Effect of blood volume management during bone tumor surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the impact of acute normovolemic hemodilution (ANH) on reducing the need for blood transfusions during bone tumor surgeries. It aims to determine if ANH, when combined with goal-directed fluid therapy, can minimize intraoperative allogeneic red blood cell transfusions, which are associated with increased postoperative complications. The study will involve patients aged 18 to 75 undergoing elective bone tumor resection, assessing blood loss and transfusion requirements. By evaluating the efficacy of ANH in this context, the trial seeks to improve patient outcomes and reduce the risks associated with blood transfusions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age 18 to 75 years;
2. undergoing elective bone tumor resection surgery;
3. preoperative hemoglobin ≥11 g/dL;

Exclusion Criteria:

1. using a tourniquet;
2. palliative operation or minimally invasive surgery;
3. BMI\<18.5 or \>30Kg/m\^2;
4. international normalized ratio (INR) \>1.5 or platelet count \<100 × 10\^9/L;
5. cardiopulmonary insufficiency;
6. hepatic and renal dysfunction;
7. active infectious disease;
8. allergy to succinyl gelatin;
9. pregnancy;
10. declined participation in the study or declined blood transfusion

Where it's running

• The Second Affiliated Hospital of Zhejiang University anesthesiology department
  Hangzhou, Zhejiang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.