Echocardiography-guided transcatheter aortic valve replacement (Echo TAVR)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses echocardiography as the primary imaging guide to perform transcatheter aortic valve replacement, avoiding routine fluoroscopy and iodinated contrast. It enrolls adults with symptomatic severe aortic stenosis who either decline or are advised against contrast or radiation, including those with high cancer risk or chronic kidney disease. Procedures will be done at a single center with collection of procedural details and short-term safety and feasibility outcomes. Key exclusions include need for hybrid/concomitant cardiac interventions, untreated revascularizable coronary disease, prior aortic valve replacement, or prohibitive surgical comorbidity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. symptomatic severe AS determined by echocardiography and Doppler that requiring aortic valve replacement, which is defined as: mean gradient ≥40 mmHg, peak aortic velocity ≥4 m/s, and aortic valve area (AVA) ≤1 cm2 (or an indexed AVA ≤0.6 cm2/m2);
2. a history of malignancy or a high familial risk of cancer, with refusal to undergo contrast- or radiation-guided procedures;
3. chronic kidney disease and refuse to receive contrast agents or radiation exposure.

Exclusion Criteria:

Required hybrid procedures or concomitant interventions on other cardiac malformations; Deemed inoperable due to extremely high surgical risk or severe comorbidities; Had untreated clinically significant coronary vascular disease amenable to revascularization; Previously undergone aortic valve replacement.

Where it's running

• Fuwai Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Xiangbin Pan, MD
• Email: panxiangbin@fuwaihospital.org
• Phone: 88396655

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Single-beat TE-e' for estimating left atrial pressure in critically ill patients

  A noninvasive test using a single-beat TE-e' echocardiography measurement is being tried to see if it can reliably indicate elevated left atrial pressure in critically ill adults.

  Recruiting Queen Mary Hospital, Hong Kong · Hong Kong · NCT07820319

• Automated Echocardiography Measurements Using Deep-Learning Software

  This study tests whether US2.AI can automatically measure heart structure and function from standard echocardiograms as accurately as expert clinicians in adults.

  Recruiting Centro Cardiologico Monzino · Milan, Lombardy · NCT07738419

• Cardiac and carotid ultrasound reference values in healthy children in Italy

  This study tests heart and artery measurements to establish normal reference values for healthy kids in Italy.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT07666451

• DigitHeart Echo: predicting heart ultrasound findings from a smartphone photo of your ECG

  This test checks whether a smartphone app can predict echocardiogram findings from a photo of a 12‑lead ECG in adults scheduled for echocardiography.

  Recruiting The University of Hong Kong · Hong Kong · NCT07558109

• COMA.NET: Targeted treatment for coronary microcirculation problems

  This trial will test whether tailoring medicines based on intracoronary microvascular testing improves quality of life for people with ischemia but no large artery blockages.

  Recruiting Medical University of Bialystok · Bialystok · NCT07498231

• Global longitudinal strain to predict difficult separation from cardiopulmonary bypass

  This will test whether a heart ultrasound measure called global longitudinal strain (GLS) can predict which adults having elective cardiac surgery will have trouble coming off cardiopulmonary bypass.

  Recruiting at 2 sites Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Rome and 1 other locations · NCT07390903

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.