Eccentric exercise training for patients with COPD
Official title: Effects of Smart Eccentric Exercise Training on Lymphocyte Immunity and Erythrocyte Rheology in Patients With Chronic Obstructive Pulmonary Disease
Run by Fu Jen Catholic University · NCT06168266 · Data updated 2026-11-12
This study is testing if a special type of exercise can help people with COPD improve their fitness, immune health, and overall quality of life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 170 (estimated) |
| Sponsor | Fu Jen Catholic University Academic / other |
| Locations | 1 site (New Taipei City) |
| Status | Recruiting |
| Started | December 13, 2023 |
| Main results expected | October 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT06168266 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are COPD patients who have completed pulmonary rehabilitation for more than three months and have received medical clearance for exercise.
✕Probably not a fit
Patients with severe heart failure, those on home oxygen therapy, or individuals with significant neuromuscular diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop eccentric exercise strategies for patients with Chronic Obstructive Pulmonary Disease (COPD) to enhance their cardiopulmonary and muscular fitness, immune function, and overall quality of life. The study will recruit COPD patients based on GOLD severity grades and will involve a series of functional tests to assess improvements. Participants will engage in eccentric exercise using specialized equipment, with blood samples taken for analysis to monitor health changes over the course of the study.
Why it matters
Potential benefit: If successful, this approach could significantly improve the fitness and quality of life for patients suffering from COPD.
How similar studies have gone: Previous studies have shown promising results with eccentric exercise approaches in similar patient populations, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having undergone pulmonary rehabilitation for more than 3 months * Sign the written informed consent form * FEV1/FVC \< 0.70 * Approval for exercise training granted by a specialist physician's assessment * Specialist physician's approval for exercise training Exclusion Criteria: * Existing of tracheostomy * Those who use oxygen therapy or ventilator at home * Severe heart failure (NYHA III-IV) * Neuromuscular disease * Acute exacerbation within the past three months * Those who are unable to cooperate with the cardiopulmonary exercise test * Taking anticoagulant medications * Other conditions restricting exercise for over a year * Recent or planned significant cardiovascular surgery or intervention * Current or planned pregnancy within the next year * Planned heart transplant within the next six months * Heart failure due to uncorrectable valvular heart disease, congenital heart disease or obstructive cardiomyopathy * Inadequate ICD settings for exercise heart rate * Other exercise contraindications: unstable angina, uncontrolled blood pressure, orthostatic hypotension with symptoms, severe aortic stenosis, acute discomfort or fever, uncontrolled arrhythmias, uncompensated heart failure, acute pericarditis or myocarditis, recent thrombosis or thrombophlebitis, resting ST-segment deviation, uncontrolled diabetes, etc.
Where it's running
-
Fu Jen Catholic University Hospital, Fu Jen Catholic University
New Taipei City, Taiwan Recruiting
Study contacts
- Principal investigator: Ke-Yun Chao, PhD — Fu Jen Catholic University Hospital
- Study coordinator: Ke-Yun Chao, PhD
- Email: C00152@mail.fjuh.fju.edu.tw
- Phone: +886905301879
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.