Eccentric cycling training for patients with fibrosing interstitial lung disease
Physical Activity and Fibrosing Interstitial Lung Disease
This study is testing if eccentric cycling can help improve physical abilities and exercise tolerance in patients with fibrosing interstitial lung disease compared to regular cycling.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Bobigny, Seine Saint Denis) |
| Trial ID | NCT06182748 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of eccentric cycling compared to concentric cycling on physical capacities in patients with fibrosing interstitial lung disease (ILD). A total of 60 patients will undergo initial assessments to evaluate their physical abilities, followed by a 12-week training program where they will be randomized into two groups for different cycling modalities. The study aims to assess improvements in exercise tolerance and the physiological mechanisms behind these benefits, using various tests to measure oxygen transport and functional capacity. Evaluations will be conducted before and after the training period to determine the impact of the interventions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with fibrosing interstitial lung disease and able to participate in physical reconditioning.
Not a fit: Patients with contraindications to physical activity or those unable to perform exercise on an ergocycle or treadmill may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance physical fitness and quality of life for patients with fibrosing interstitial lung disease.
How similar studies have performed: While eccentric cycling has shown feasibility in chronic obstructive pulmonary disease, its application in fibrosing interstitial lung disease is novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged ≥ 18 years * Fibrosing PID with fibrosis score \> 10% of lung volume on chest CT scan * Be able to attend physical reconditioning 3 times a week * Be affiliated to a health insurance scheme * Sign informed consent form Exclusion Criteria: * Any contraindication to physical activity (hereafter, after Dany-Michel Marcadeta, Bruno Pavy et al. Recommendations of the French Society of Cardiology for stress tests 2018) * Be unable to perform exercise on an ergocycle or treadmill * Be unable to perform a stress test, particularly for people on long-term oxygen therapy rest oxygen therapy at home * IRS during an exacerbation * Change in treatment \< 3 months * Sarcoidosis * Connectivitis * Pregnancy in progress * Participation in a therapeutic intervention study * Patient under guardianship * Person subject to a legal protection measure * Patient on state medical aid
Where this trial is running
Bobigny, Seine Saint Denis
- Exercise and Sports Medicine Department — Bobigny, Seine Saint Denis, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.