Eccentric cycling exercise for patients with pulmonary vascular disease
Eccentric Cycling Exercise During Pulmonary Rehabilitation in Pulmonary Vascular Disease
This study is testing if eccentric cycling exercise can help people with pulmonary vascular disease improve their exercise ability and overall health during rehabilitation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 22 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University of Zurich Academic / other |
| Locations | 2 sites (Erlinsbach and 1 other locations) |
| Trial ID | NCT06480656 on ClinicalTrials.gov |
What this trial studies
This project investigates the effects of eccentric cycling exercise (ECC) on exercise capacity and hemodynamics in patients with pulmonary vascular disease (PVD). ECC allows for high-intensity training with low metabolic costs, making it a potentially valuable exercise modality for these patients. The study aims to determine if ECC can enhance the benefits of prolonged rehabilitation programs, building on previous findings that suggest ECC improves muscle strength, walking distance, and oxygen uptake in similar patient populations. Participants will undergo rehabilitation that includes ECC compared to standard rehabilitation methods.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 to 85 diagnosed with pulmonary vascular disease, either pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH), who are stable on medication.
Not a fit: Patients with co-morbidities that limit their ability to participate in full rehabilitation or those enrolled in other active treatment trials may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve exercise capacity and overall health outcomes for patients with pulmonary vascular disease.
How similar studies have performed: Previous studies have shown that eccentric cycling exercise can be effective in improving outcomes for patients with chronic obstructive pulmonary disease and other cardiovascular conditions, suggesting potential success for this approach in PVD.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with PVD, either PAH or CTEPH according to recent guidelines * Stable medication for at least 1 month * Age 18 to 85 years * No resting hypoxemia (PaO2 \>7.3kPa) Exclusion Criteria: * Any co-morbidity that limits the patient to participate the full rehabilitation * Enrollments in other trials with active treatments
Where this trial is running
Erlinsbach and 1 other locations
- Rehabilitation clinic Barmelweid — Erlinsbach, Switzerland (Recruiting)
- University Hospital Zurich, Pneumology — Zurich, Switzerland (Recruiting)
Study contacts
- Study coordinator: Silvia Ulrich, Prof
- Email: silvia.ulrich@usz.ch
- Phone: 0442564362
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.