Eccentric cycling exercise for patients with chronic kidney disease
To Explore Efficacy and Load of Eccentric Cycling Training in Older CKD Patients with or Without Sarcopenia
This study is testing if a special type of cycling exercise can help people with chronic kidney disease feel better and improve their overall health compared to regular cycling or usual care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 55 Years to 85 Years |
| Sex | All |
| Sponsor | National Cheng Kung University Academic / other |
| Locations | 1 site (Tainan, Taiwan) |
| Trial ID | NCT06551311 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of an eccentric cycling exercise program on patients with chronic kidney disease (CKD). It aims to assess improvements in body composition, functional capacity, flexibility, muscle strength, exercise capacity, pulmonary function, quality of life, and renal function. Participants will be randomly assigned to one of three groups: eccentric cycling exercise, concentric cycling exercise, or usual care. The study is conducted in collaboration with the Departments of Nephrology and Geriatric Medicine at National Cheng Kung University Hospital in Taiwan.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with chronic kidney disease who have an eGFR less than 60 ml/min/1.73m² or are undergoing routine dialysis.
Not a fit: Patients with acute renal failure or severe joint disorders may not benefit from this exercise program.
Why it matters
Potential benefit: If successful, this program could significantly enhance the quality of life and physical capabilities of patients with chronic kidney disease.
How similar studies have performed: While previous studies have explored exercise in CKD patients, this specific approach of eccentric cycling exercise is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
This study will be conducted in collaboration with the Departments of Nephrology and Geriatric Medicine at National Cheng Kung University Hospital, Taiwan. Participants will be recruited as voluntary subjects from outpatient clinics. The attending physician will assess eligible patients. After the study's purpose and methodology are explained by the research staff and patients consent to participate, block randomization will be used to assign participants into one of three groups randomly. The allocation results will be securely stored by the principal investigator. Inclusion Criteria: * (1) Clinical diagnosis of CKD * (2) eGFR \<60 ml/min/1.73m\^2 or undergoing routine dialysis * (3) Must be able to communicate normally, understand and comply with instructions. * (4) Must be able to walk independently. Exclusion Criteria: * (1) Clinical diagnosis of acute renal failure * (2) Hospitalization for acute illness within the past three months * (3) Clinical diagnosis of severe joint disease and lower extremity surgery * (4) Clinical diagnosis of severe neurological disease * (5) Clinical diagnosis of severe cardiovascular disease * (6) Unconsciousness or lack of ability to cooperate with the assessment
Where this trial is running
Tainan, Taiwan
- National Cheng Kung University Hostipal — Tainan, Taiwan, Taiwan (Recruiting)
Study contacts
- Study coordinator: Kun-Ling Tsai, Ph.D.
- Email: kunlingtsai@mail.ncku.edu.tw
- Phone: 886-6-2353535 Ext. 6219
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.