Clinical trial Recruiting at 1 site Observational Ages 40 to 65

Early warning system for cognitive impairment in diabetes

Official title: The Early Warning System for the Central Nervous System Micro-structure Alterations During Early Diabetes Based on the Multi-mode MRIs

Run by Tang-Du Hospital · NCT02420470 · Data updated 2026-11-12

This study is testing a new way to spot early signs of brain changes in people with type 2 diabetes and mild cognitive impairment to help prevent further cognitive decline.

Quick facts

Study typeObservational
Ages40 Years to 65 Years
SexAll
Enrollment300 (estimated)
SponsorTang-Du Hospital
Academic / other
Locations1 site (Xi'an, Shaanxi)
StatusRecruiting
StartedApril 2015
Main results expectedNovember 2025
Study endsDecember 2026
Registry record updatedJuly 13, 2022
Trial IDNCT02420470 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with type 2 diabetes who do not have dementia and have completed at least six years of education.

Probably not a fit

Patients with serious brain diseases, pregnant women, or those with contraindications for MRI will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on identifying cerebral abnormalities in patients with type 2 diabetes and mild cognitive impairment using advanced multi-parametric functional MRI techniques. The study aims to establish an early warning system for detecting central nervous system micro-structural alterations associated with diabetes. By integrating psychological assessments and clinical biochemical examinations, the researchers will evaluate the relationship between these cerebral biomarkers and cognitive decline. The findings may help in monitoring prediabetic conditions and preventing progression to diabetes-related cognitive issues.

Why it matters

Potential benefit: If successful, this study could lead to early detection and intervention strategies for cognitive impairment in diabetic patients.

How similar studies have gone: While there is ongoing research into cognitive impairment in diabetes, this specific approach using multi-modal MRI techniques is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* without dementia
* Inform Consent Form
* Education time more than 6 years
* blood glucose matches the group standard

Exclusion Criteria:

* Pregnant woman
* suffer from serious brain disease
* Magnetic resonance contraindications
* lack of compliance
* image quality is too poor to deal with

Where it's running

  • Tangdu Hospital
    Xi'an, Shaanxi, China
    Recruiting

Study contacts

  • Study coordinator: Guangbin Cui, professor
  • Email: cgbtd@126.com

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.