Early warning system for cognitive impairment in diabetes
Official title: The Early Warning System for the Central Nervous System Micro-structure Alterations During Early Diabetes Based on the Multi-mode MRIs
Run by Tang-Du Hospital · NCT02420470 · Data updated 2026-11-12
This study is testing a new way to spot early signs of brain changes in people with type 2 diabetes and mild cognitive impairment to help prevent further cognitive decline.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 65 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Tang-Du Hospital Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Status | Recruiting |
| Started | April 2015 |
| Main results expected | November 2025 |
| Study ends | December 2026 |
| Registry record updated | July 13, 2022 |
| Trial ID | NCT02420470 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with type 2 diabetes who do not have dementia and have completed at least six years of education.
✕Probably not a fit
Patients with serious brain diseases, pregnant women, or those with contraindications for MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on identifying cerebral abnormalities in patients with type 2 diabetes and mild cognitive impairment using advanced multi-parametric functional MRI techniques. The study aims to establish an early warning system for detecting central nervous system micro-structural alterations associated with diabetes. By integrating psychological assessments and clinical biochemical examinations, the researchers will evaluate the relationship between these cerebral biomarkers and cognitive decline. The findings may help in monitoring prediabetic conditions and preventing progression to diabetes-related cognitive issues.
Why it matters
Potential benefit: If successful, this study could lead to early detection and intervention strategies for cognitive impairment in diabetic patients.
How similar studies have gone: While there is ongoing research into cognitive impairment in diabetes, this specific approach using multi-modal MRI techniques is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * without dementia * Inform Consent Form * Education time more than 6 years * blood glucose matches the group standard Exclusion Criteria: * Pregnant woman * suffer from serious brain disease * Magnetic resonance contraindications * lack of compliance * image quality is too poor to deal with
Where it's running
-
Tangdu Hospital
Xi'an, Shaanxi, China Recruiting
Study contacts
- Study coordinator: Guangbin Cui, professor
- Email: cgbtd@126.com
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Proliverenol for liver fat and insulin resistance in type 2 diabetes
This study tests whether adding Proliverenol to standard diabetes care can improve liver fat and blood sugar control in adults with type 2 diabetes.
-
Whole-Body Vibration Training in Women With Obesity With and Without Type 2 Diabetes
This study tests whether eight weeks of supervised whole-body vibration training changes ankle muscle activity and walking performance in women with obesity, comparing those with and without type 2 diabetes.
-
Safety test of NNC9836-0001 in adults with overweight/obesity or type 2 diabetes
This study tests whether the new medicine NNC9836-0001 is safe and tolerable in adults who are overweight or have type 2 diabetes, compared to placebo.
-
RIGHTEST iFree 2 CGM in Pregnant Women With Diabetes
This study tests the accuracy and safety of the RIGHTEST iFree 2 continuous glucose monitor in pregnant adults with type 1, type 2, or gestational diabetes.
-
One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions
A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.
-
EloraTZP for weight loss in adults with overweight/obesity and type 2 diabetes
This trial tests whether a coformulation of eloralintide and tirzepatide helps people with obesity or overweight and type 2 diabetes lose weight compared with tirzepatide alone.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.