Early warning system for cognitive impairment in diabetes
The Early Warning System for the Central Nervous System Micro-structure Alterations During Early Diabetes Based on the Multi-mode MRIs
Tang-Du Hospital · NCT02420470
This study is testing a new way to spot early signs of brain changes in people with type 2 diabetes and mild cognitive impairment to help prevent further cognitive decline.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 40 Years to 65 Years |
| Sex | All |
| Sponsor | Tang-Du Hospital (other) |
| Locations | 1 site (Xi'an, Shaanxi) |
| Trial ID | NCT02420470 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on identifying cerebral abnormalities in patients with type 2 diabetes and mild cognitive impairment using advanced multi-parametric functional MRI techniques. The study aims to establish an early warning system for detecting central nervous system micro-structural alterations associated with diabetes. By integrating psychological assessments and clinical biochemical examinations, the researchers will evaluate the relationship between these cerebral biomarkers and cognitive decline. The findings may help in monitoring prediabetic conditions and preventing progression to diabetes-related cognitive issues.
Who should consider this trial
Good fit: Ideal candidates include individuals with type 2 diabetes who do not have dementia and have completed at least six years of education.
Not a fit: Patients with serious brain diseases, pregnant women, or those with contraindications for MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to early detection and intervention strategies for cognitive impairment in diabetic patients.
How similar studies have performed: While there is ongoing research into cognitive impairment in diabetes, this specific approach using multi-modal MRI techniques is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * without dementia * Inform Consent Form * Education time more than 6 years * blood glucose matches the group standard Exclusion Criteria: * Pregnant woman * suffer from serious brain disease * Magnetic resonance contraindications * lack of compliance * image quality is too poor to deal with
Where this trial is running
Xi'an, Shaanxi
- Tangdu Hospital — Xi'an, Shaanxi, China (RECRUITING)
Study contacts
- Study coordinator: Guangbin Cui, professor
- Email: cgbtd@126.com
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Diabetes Mellitus Type 2, Mild Cognitive Impairment, Metabolic Syndrome X, diabetes, neural and vessel alteration, prodromal stage