Early versus delayed catheter removal in men with sudden urinary retention

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult men who present with acute urinary retention and are treated with a transurethral catheter plus an alpha-blocker will be enrolled and assigned to have a Trial Without Catheter (TWOC) after either 3 days or 14 days. Outcomes such as successful voiding, catheter-related complications, and urinary tract infections will be recorded and compared between the two timing groups. The trial excludes men with neurogenic bladder, large initial retention volumes, recent failed TWOC, or certain prostate/bladder cancer histories. Participating sites are regional hospitals in the Netherlands where procedures and follow-up visits will take place.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult men (≥18 years)
* Diagnosis of acute urinary retention (AUR) treated with a transurethral catheter (TUC) and alpha-blocker therapy (tamsulosin, silodosin, or alfuzosin)
* Mentally competent and able to understand the potential benefits and burdens of study participation
* Provision of written or digital informed consent

Exclusion Criteria:

* Failed prior TWOC within the preceding 30 days
* Initial urinary retention volume \>1500 mL
* Neurogenic bladder dysfunction (e.g., multiple sclerosis, spinal cord injury, spina bifida)
* History of prostate cancer with ISUP grade group ≥2
* History of active bladder cancer or ongoing surveillance for bladder cancer
* Urinary retention occurring within 72 hours after surgery (postoperative urinary retention)
* History of lower urinary tract surgery (e.g., bladder augmentation, urethral surgery, or prostate surgery)
* AUR suspected to be caused by bladder stones
* Suspected urethral stricture, clot retention, or urosepsis
* Contraindication to alpha-blocker therapy

Where it's running

• Canisius Wilhelmina Hospital
  Nijmegen, Gelderland, Netherlands Recruiting
• Maastricht University Medical Center+
  Maastricht, Limburg, Netherlands Recruiting
• Catharina Hospital
  Eindhoven, North Brabant, Netherlands Recruiting
• Olvg
  Amsterdam, North Holland, Netherlands Recruiting
• Isala
  Zwolle, Overijssel, Netherlands Recruiting
• Martini Hospital
  Groningen, Provincie Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Bart P.W. Witte, MD, PhD — Isala
• Study coordinator: Liselot L.A. Ribbert, MD,. PhD candidate
• Email: liselotribbert@hotmail.com
• Phone: +31653182448

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.