Early transfer of culture medium before embryo transfer
Official title: Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s). Randomized, Single-blind, Multicenter Controlled Trial.
Run by Centre Hospitalier Universitaire de Nīmes · NCT06177613 · Data updated 2026-11-12
This study is testing if putting a special fluid in the uterus before transferring frozen embryos can help women who have had trouble getting pregnant in the past.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | Women only |
| Enrollment | 1154 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nīmes Academic / other |
| Locations | 7 sites (Clamart and 6 other locations) |
| Status | Recruiting |
| Started | February 9, 2024 |
| Main results expected | May 2026 |
| Study ends | February 2027 |
| Registry record updated | February 20, 2025 |
| Trial ID | NCT06177613 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women who have experienced a failed embryo transfer and have frozen embryos available for transfer.
✕Probably not a fit
Patients who have not experienced a previous embryo transfer failure or those with embryos not at the D3 stage may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the benefits of transferring a 'blank' culture medium into the uterus before the transfer of thawed embryos in patients who have previously experienced implantation failure. The aim is to enhance the communication between the embryo and the uterine lining, potentially improving the chances of successful implantation. The study will involve patients who have undergone a prior embryo transfer that did not result in pregnancy, focusing on those with frozen embryos at the D3 stage. Participants will be randomly assigned to receive either the culture medium transfer or a sham transfer.
Why it matters
Potential benefit: If successful, this approach could significantly improve pregnancy rates for patients undergoing single embryo transfers.
How similar studies have gone: While there have been studies on sequential embryo transfers, the specific approach of early culture medium transfer is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having had a first "fresh" or frozen embryo transfer, whatever the embryo's stage of development, transfer followed by pregnancy failure ; * Frozen embryos must be at least D3 stage; * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan Exclusion Criteria: * The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study * The patient is under safeguard of justice or state guardianship
Where it's running
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CHU de Nîmes
Nîmes, France Recruiting -
Hôpital Antoine Béclère
Clamart, France Not yet recruiting -
Centre Hospitalier Alpes Léman
Contamine-sur-Arve, France Not yet recruiting -
CHU Arnaud de Villeneuve
Montpellier, France Not yet recruiting -
Clinique Saint Roch
Montpellier, France Not yet recruiting -
Clinique Saint-Pierre
Perpignan, France Not yet recruiting
Show 1 more location
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CHU de la Réunion
Saint-Pierre, Reunion Not yet recruiting
Study contacts
- Principal investigator: Nathalie Rougier — CHU de Nimes
- Study coordinator: Nathalie Rougier
- Email: nathalie.rougier@chu-nimes.fr
- Phone: 04.66.68.32.24
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This trial tests whether injecting sperm into eggs (ICSI) or mixing eggs with frozen donor sperm (conventional IVF) makes more and better embryos for people using frozen donor sperm without male‑factor infertility.
-
Best follicle size for triggering ovulation in women 35+ with low ovarian reserve (POSEIDON Group 4)
This study will see if triggering ovulation when follicles measure 13–16 mm rather than waiting until >17 mm yields more mature eggs for women 35 and older with low ovarian reserve undergoing IVF.
-
Investigating the impact of sexual intercourse on embryo transfer outcomes
This study is testing if having sex the night after a frozen embryo transfer helps improve the chances of pregnancy for women undergoing this procedure.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.