Early prehospital ketamine plus midazolam for convulsive status epilepticus in children with epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

PEAK-SEEK is a pragmatic, decentralized, pre-consented, event-driven randomized controlled trial comparing add-on intramuscular ketamine to a second prehospital dose of midazolam versus standard midazolam-based care for pediatric convulsive status epilepticus. Eligible children are aged 2–16 years with an established epilepsy diagnosis of at least one year and a recent history of convulsive status epilepticus; enrollment occurs at the index prehospital event. Emergency responders administer the randomized intervention in the field to try to shorten seizure duration and reduce progression to refractory or prolonged status epilepticus. The trial is designed to reflect real-world emergency conditions and measure whether earlier combination therapy reduces seizure time and downstream complications compared with midazolam alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 2 to 16 years.
* Established diagnosis of epilepsy of at least 1 year duration.
* History of at least 1 episode of convulsive status epilepticus in the preceding 12 months.

Exclusion Criteria:

* Failure to obtain informed consent.
* Known allergies or contraindications to ketamine.
* Known contraindications to intramuscular injection.
* Presence of another family member included in the same trial.
* Having subsequent events (only the index event will be included).

Where it's running

• Department of Pediatrics at Sohag University Hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Elsayed Abdelkreem
• Email: d.elsayedmohammed@med.sohag.edu.eg
• Phone: 1114232126

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ketamine added to levetiracetam to stop prolonged convulsive seizures

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• Improving prognosis for patients with Status Epilepticus

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.