Early diagnosis and treatment of gastric cancer using targeted imaging techniques
Official title: Research on Early Diagnosis and Clinical Transformation of Nuclide Probe Based on Bioorthogonal-gastric Cancer Mucin Target Visualization
Run by Peking University Cancer Hospital & Institute · NCT06429891 · Data updated 2026-11-12
This study is testing a new way to find and treat gastric cancer earlier by using special imaging techniques and a targeted antibody that focuses on a specific protein in tumors.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Peking University Cancer Hospital & Institute Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | August 20, 2024 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | August 22, 2024 |
| Trial ID | NCT06429891 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with histologically confirmed solid tumors and measurable lesions.
✕Probably not a fit
Patients with significant hepatic or renal dysfunction, or those who are pregnant, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project focuses on the early diagnosis of gastric cancer, which often presents with insidious symptoms leading to late-stage detection. It investigates the characteristics of the tumor microenvironment related to the MUC family of glycoproteins in solid tumors. Utilizing advanced techniques such as immunohistochemistry and gene sequencing, the study aims to develop a specific monoclonal antibody targeting MUC1, which could enhance the detection and treatment of gastric cancer. The approach includes innovative spatial analysis methods to better understand tumor biology and resistance mechanisms.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and more effective treatment options for patients with gastric cancer.
How similar studies have gone: While similar approaches have been explored, this specific methodology targeting the MUC family in gastric cancer is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged ≥18 years old; ECOG 0 or 1; 2. Patients with solid tumor confirmed by histopathology; 3. Patients with imaging confirmed measurable lesions; 4. life expectancy \>=12 weeks. Exclusion Criteria: 1. Significant hepatic or renal dysfunction; 2. ls pregnant or ready to pregnant; 3. Cannot keep their states for half an hour; 4. Refusal to join the clinical study; 5. Suffering from claustrophobia or other mental diseases; 6. Any other situation that researchers think it is not suitable to participate in the experiment.
Where it's running
-
Beijing Cancer Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Hua Zhu — Peking University Cancer Hospital & Institute
- Study coordinator: Hua Zhu
- Email: zhuhuabch@pku.edu.cn
- Phone: +861088196495
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.