Early detection of chronic thromboembolic pulmonary hypertension after a pulmonary embolism
Official title: Early Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients After Acute Pulmonary Embolism
Run by Institute of Health Information and Statistics of the Czech Republic · NCT06865326 · Data updated 2026-11-12
This project will test a standardized screening program to see if it finds chronic thromboembolic pulmonary hypertension (CTEPH) earlier in adults who had an acute pulmonary embolism 3–12 months earlier.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Institute of Health Information and Statistics of the Czech Republic Government |
| Locations | 10 sites (Brno and 9 other locations) |
| Status | Recruiting |
| Started | March 7, 2025 |
| Main results expected | December 31, 2027 |
| Study ends | June 30, 2028 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT06865326 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who are on anticoagulation and had an acute pulmonary embolism 3–12 months ago with new or worsening dyspnea or at least one high-risk feature for CTEPH are the ideal candidates.
✕Probably not a fit
People under 18, those outside the 3–12 month post-embolism window, asymptomatic patients without risk factors, or patients unable to attend participating Czech centers are unlikely to benefit from this screening pilot.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a national, prospective, multicenter observational pilot screening about 500 adults across roughly 10 Czech centers using a standardized CTEPH screening protocol. Eligible participants are adults on anticoagulation who had an acute pulmonary embolism 3–12 months earlier and either have new or worsening dyspnea or predefined risk factors for CTEPH. The protocol uses echocardiography and an algorithm-driven pathway for rapid referral to specialized pulmonary hypertension centers for confirmatory testing and treatment where indicated. The project will validate the screening workflow, measure feasibility and patient flow, and review cost-effectiveness before broader implementation.
Why it matters
Potential benefit: If successful, the program could diagnose CTEPH earlier so patients receive timely specialist care that improves quality of life and reduces complications and risk of death.
How similar studies have gone: Targeted screening and rapid referral for CTEPH after pulmonary embolism have shown benefit in prior single-center and observational cohorts, but a standardized national multicenter pilot like this is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age over 18 years * Signed consent to participate in the project and GDPR * Patients with an episode of acute pulmonary embolism in the last 3-12 months, with ongoing anticoagulation therapy: 1. Patients with new-onset and ongoing or progressive dyspnea (min. NYHA II) after a pulmonary embolism episode or worsening of dyspnea after a pulmonary embolism episode compared to the status before the episode (at least 1 HYHA grade) or 2. Asymptomatic patients after a pulmonary embolism episode and at least one of the following risk factors: * ECHO evidence of severe PH at diagnosis of PE (PASP \>60 mmHg) * Antiphospholipid syndrome with triple positivity (presence of lupus anticoagulans + anti-beta-2-glycoprotein I (B2GPI) antibodies + anticardiolipin) * Infected permanent venous inlets and cardiac pacing/defibrillation intravascular systems * Presence of ventriculoatrial shunt for treatment of hydrocephalus * Nonspecific intestinal inflammation (ulcerative colitis, Crohn's disease) * History of splenectomy * Myeloproliferative disorders * Chronic osteomyelitis Exclusion Criteria: * Not agreeing to participate in the project * Contraindications to treatment
Where it's running
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Brno University Hospital
Brno, Czechia Recruiting -
Havlíčkův Brod Hospital
Havlíčkův Brod, Czechia Recruiting -
University Hospital Hradec Králové
Hradec Králové, Czechia Recruiting -
Jihlava Hospital
Jihlava, Czechia Recruiting -
Náchod Hospital
Náchod, Czechia Recruiting -
University Hospital Olomouc
Olomouc, Czechia Recruiting
Show 4 more locations
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University Hospital Ostrava
Ostrava, Czechia Recruiting -
Pardubice Hospital
Pardubice, Czechia Recruiting -
Rychnov nad Kněžnou Hospital
Rychnov nad Kněžnou, Czechia Recruiting -
Tábor Hospital
Tábor, Czechia Recruiting
Study contacts
- Study coordinator: Nikola Štourač
- Email: nikola.stourac@uzis.cz
- Phone: +420 739 012 354
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This study is testing a new way to diagnose heart problems in people who get short of breath during exercise by using special tests that look at how the heart and lungs work together.
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Comparing FlowTriever System to Standard Care for High-Risk Pulmonary Embolism
This study tests if the FlowTriever System can help people with high-risk pulmonary embolism feel better compared to standard treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.