Early detection and prevention of symptomatic post-surgical hypoparathyroidism after thyroid surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls adults undergoing total or bilateral thyroidectomy and performs early perioperative measurements of parathyroid hormone, calcium, and vitamin D, using an algorithm to guide prompt calcium and active vitamin D supplementation when indicated. Baseline data and patient-reported outcomes (SF-36, STAI-G, HPQ28, and a modified HPES symptom scale) are collected, with postoperative clinical visits on days 0, 1, and 2 and a planned six-month follow-up. Recruitment is planned over three years at the University Hospital Wuerzburg and excludes patients with preexisting parathyroid disease, prior neck surgery, pregnancy or breastfeeding, or inability to attend visits. The goal is to create a clear perioperative management algorithm to reduce symptomatic hypoparathyroidism, improve quality of life, and potentially shorten hospital stays.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Thyroidectomy or bilateral thyroid resection of any indication
* Written informed consent obtained after detailed patient information and provision of an information sheet

Exclusion Criteria:

* Age ≤ 18 years
* Concomitant parathyroid disease (primary or secondary hyperparathyroidism, pre-existing hypoparathyroidism of any cause)
* Previous surgery in the neck region
* Pregnancy or breastfeeding
* Inability to attend study visits
* Participation in another study that interferes with the endpoints
* Missing or inadequate patient information

Where it's running

• Dept. Surgery I; University Hospital Wuerzburg
  Würzburg, Bavaria, Germany Recruiting

Study contacts

• Principal investigator: Nicolas Schlegel, Prof. Dr. (MD) — Wuerzburg University Hospital
• Study coordinator: Nicolas Schlegel, Prof. Dr. (MD)
• Email: SCHLEGEL_N@ukw.de
• Phone: +49 931 201 38217

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.