Early Detection and Early Treatment in Heart Failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study tests a combined strategy to detect heart failure earlier and start treatment sooner in adults aged 65 and older undergoing specific cardiac procedures or presenting to the emergency department with tachyarrhythmias. The strategy includes raising awareness among patients and clinicians, implementing NT-proBNP testing for early diagnosis, and initiating timely treatment to improve outcomes. The trial assesses whether this approach can lower hospitalization rates related to heart failure and slow disease progression. Enrollment is limited to participants meeting specific eligibility criteria and excludes those with established heart failure, certain comorbidities, or non-residence in the recruiting country. Primary sponsor is University Hospital Basel, with international sites in Vienna, Sofia, and Freiburg.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* General consent (GC) has not been rejected.
* Age ≥ 65 years.
* Elective percutaneous coronary intervention\* (PCI), pulmonary vein isolation\* (PVI), pacemaker implantation\* (PM, no cardiac resynchronisation), transcatheter aortic valve intervention\* (TAVI), major non-cardiac surgery\* or presenting with tachyarrhythmia to the emergency department (ED) (without a diagnosis of HF within 24h).

  * Exclusion criteria are assessed on day 1 after the procedure

Exclusion Criteria:

* Systolic blood pressure ≤ 95 mmHg
* Estimated glomerular filtration rate (GFR) \<30 mL/min/1.73 m2.
* Dementia documented in the medical history.
* Metastatic cancer in the medical history.
* Previously enrolled in this study.
* Known HF.
* Known allergies, hypersensitivity, or intolerance to SGLT2 Inhibitors / Loop Diuretics / MRA or is excipients.
* Non-resident in the country of the recruiting site
* Incapacity of the patient to make judgements
* Patients not hospitalized overnight
* Patients requiring intensive care unit (ICU) or intermediate care (IMC) stay beyond 11:00 a.m. on the first postoperative day or any post-interventional stroke unit stay until 8:00 a.m. on the first postoperative day.
* Patients died prior to postinterventional day 1 (8:00 a.m.)
* Severe aortic or mitral stenosis

Where it's running

• Konkuk University Medical Center
  Seoul, South Korea Recruiting
• University Hospital Basel
  Basel, Basel, Switzerland Recruiting
• Universitätsklinik für Innere Medizin II
  Vienna, Austria Not yet recruiting
• Queen Giovanna University Hospital
  Sofia, Bulgaria Not yet recruiting
• University Hospital Freiburg-Bad Krozingen
  Freiburg im Breisgau, Germany Not yet recruiting
• Universitätsklinikum der Ruhr-Universität Bochum
  Herne, Germany Not yet recruiting

Study contacts

• Study coordinator: Christian Müller, Prof. Dr.
• Email: Christian.Mueller@usb.ch
• Phone: +41 61 328 65 49

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-Invasive Heart Failure Monitoring in Hospitalized Patients

  This study tests whether daily non-invasive thoracic measurements from the Acorai Device 1.0 can relate to health outcomes for adults hospitalized with heart failure.

  Recruiting Acorai AB · Lund · NCT07671742

• New ways to estimate left heart pressures in people with heart failure and atrial fibrillation

  This study tests a new approach that combines ultrasound and clinical data to see if doctors can better tell when the heart’s filling pressure is high in patients who have both heart failure and atrial fibrillation.

  Recruiting Oslo University Hospital · Cleveland, Ohio and 14 other locations · NCT07436299

• Left bundle branch pacing plus ICD for people with hypertrophic cardiomyopathy after myectomy

  This study will test whether adding left bundle branch pacing to a dual‑chamber ICD helps people with hypertrophic cardiomyopathy who develop left bundle branch block after myectomy to slow heart failure progression and prevent life‑threatening arrhythmias.

  Recruiting Meshalkin Research Institute of Pathology of Circulation · Novosibirsk, Novosibirsk Oblast · NCT07372196

• Home-based Tai Chi program for heart failure patients and their caregivers

  This study is testing whether a home-based Tai Chi program can help heart failure patients feel better and make it easier for their caregivers to support them.

  Recruiting The Hong Kong Polytechnic University · Qingdao, Shandong · NCT06876441

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.