Ear-based vagus nerve stimulation to improve reaction time
Official title: Enhancing Reaction Time Through Non-Invasive Vagus Nerve Stimulation
Run by Youngstown State University · NCT07528742 · Data updated 2026-11-12
Researchers will try a short, noninvasive electrical stimulation of the vagus nerve at the ear to see if it shortens reaction time in healthy adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Youngstown State University Academic / other |
| Locations | 1 site (Youngstown, Ohio) |
| Status | Recruiting |
| Started | April 6, 2026 |
| Main results expected | April 5, 2027 |
| Study ends | April 5, 2027 |
| Registry record updated | April 14, 2026 |
| Trial ID | NCT07528742 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18 and older who have not previously received vagus nerve stimulation and who do not have disqualifying implants or substance abuse history are ideal candidates.
✕Probably not a fit
People with implanted cardiac or cranial devices, metal in the skull, active alcohol or drug abuse, or women in the third trimester of pregnancy are unlikely to be eligible or benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional pilot delivers transcutaneous vagus nerve stimulation using a TENS unit with electrodes clipped to the ear over the vagus nerve distribution. Stimulation is set to 30 Hz, 250 µs pulse width for 5 minutes at a comfortable, nonpainful intensity and is applied by a licensed physical therapist. Reaction time is measured using an online reaction time testing platform immediately before and after stimulation to detect within-subject changes. The single-center visit is conducted at Youngstown State University and enrolls healthy adults over age 18 who have not previously received vagus nerve stimulation.
Why it matters
Potential benefit: If successful, this could provide a simple, noninvasive way to shorten reaction time in healthy adults and inform approaches for cognitive or performance enhancement.
How similar studies have gone: Previous small studies of transcutaneous vagus nerve stimulation have shown mixed but promising effects on attention and reaction time.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy participants over the age of 18 * did not receive vagus nerve stimulation previously Exclusion Criteria: * alcohol or drug abuse * metal in the skull * implanted cardiac or cranial devices * Women during 3 trimester of pregnancy
Where it's running
-
Youngstown State University
Youngstown, Ohio, United States Recruiting
Study contacts
- Study coordinator: Weiqing Ge Ge, DPT, PhD
- Email: wge@ysu.edu
- Phone: 330-941-2702
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Bioequivalence comparison between YHP2508B and YHR2602 in healthy adults
This study tests whether YHP2508B and YHR2602 deliver similar amounts of the drug in healthy adults after a single dose.
-
Bioequivalence test of two drugs in healthy adults
This study tests whether YHP2508A and YHR2601 are bioequivalent in healthy volunteers.
-
Reactive Balance Training with Augmented Reality for Older Adults
This study tests whether reactive balance training using augmented reality helps older adults who are at risk of falling, compared with regular treadmill walking.
-
How the body responds to exercise with low oxygen in healthy adults
Researchers test how healthy men and women respond to different exercise types while breathing air with varying oxygen levels.
-
IS M8969 safety and PK/PD in healthy and at-risk adults
This early-phase study tests ISM8969 versus placebo to see if it is safe, well tolerated, and how the body handles and responds to it in healthy adults and obese adults at risk for heart disease.
-
Single ascending-dose safety and response test of SYH2070 injection in healthy adults
This test gives a single subcutaneous dose of SYH2070 to healthy adults with mildly high triglycerides to see whether it is safe, how the body handles it, and whether it causes early biological effects compared with placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.