Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Ear-based vagus nerve stimulation to improve reaction time

Official title: Enhancing Reaction Time Through Non-Invasive Vagus Nerve Stimulation

Run by Youngstown State University · NCT07528742 · Data updated 2026-11-12

Researchers will try a short, noninvasive electrical stimulation of the vagus nerve at the ear to see if it shortens reaction time in healthy adults.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorYoungstown State University
Academic / other
Locations1 site (Youngstown, Ohio)
StatusRecruiting
StartedApril 6, 2026
Main results expectedApril 5, 2027
Study endsApril 5, 2027
Registry record updatedApril 14, 2026
Trial IDNCT07528742 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Healthy adults aged 18 and older who have not previously received vagus nerve stimulation and who do not have disqualifying implants or substance abuse history are ideal candidates.

Probably not a fit

People with implanted cardiac or cranial devices, metal in the skull, active alcohol or drug abuse, or women in the third trimester of pregnancy are unlikely to be eligible or benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional pilot delivers transcutaneous vagus nerve stimulation using a TENS unit with electrodes clipped to the ear over the vagus nerve distribution. Stimulation is set to 30 Hz, 250 µs pulse width for 5 minutes at a comfortable, nonpainful intensity and is applied by a licensed physical therapist. Reaction time is measured using an online reaction time testing platform immediately before and after stimulation to detect within-subject changes. The single-center visit is conducted at Youngstown State University and enrolls healthy adults over age 18 who have not previously received vagus nerve stimulation.

Why it matters

Potential benefit: If successful, this could provide a simple, noninvasive way to shorten reaction time in healthy adults and inform approaches for cognitive or performance enhancement.

How similar studies have gone: Previous small studies of transcutaneous vagus nerve stimulation have shown mixed but promising effects on attention and reaction time.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Healthy participants over the age of 18
* did not receive vagus nerve stimulation previously

Exclusion Criteria:

* alcohol or drug abuse
* metal in the skull
* implanted cardiac or cranial devices
* Women during 3 trimester of pregnancy

Where it's running

  • Youngstown State University
    Youngstown, Ohio, United States
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.