Dutasteride plus aloe vera to improve urine flow and reduce prostate enlargement in men with BPH

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a double-blind, randomized controlled Phase 1 trial comparing a combination of dutasteride plus aloe vera extract versus dutasteride alone with measurements taken before and after 12 weeks of treatment. Primary outcomes include uroflowmetry (Qmax), prostate volume, and serum VEGF level. Eligible participants are men with clinically or radiologically confirmed BPH who have not used alpha blockers or 5-ARIs in the prior six months and who do not have complicating conditions such as urinary retention or suspected prostate cancer. The intervention is administered at a single center and blinded to participants and investigators to reduce bias.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with BPH clinically or radiologically (prostate volume \> 30 gram, Qmax \<15 mL/s)
* Willing to participate to the study

Exclusion Criteria:

* Clinically or radiologically suspected of having prostatic cancer
* Previous prostatic surgery
* Patients with urinary retention
* Patients with BPH complications: urinary tract infections, urolithiasis, or hydroneprhosis
* Previously consumed alpha blocker or 5ARI in the last 6 months
* Have consumed aloe vera extract routinely

Where it's running

• RSUD Karawang
  Karawang, West Java, Indonesia Recruiting

Study contacts

• Study coordinator: Achmad Rizky Herda Pratama dr. Achmad Rizky Herda Pratama, Sp.U, S.H, Urologist
• Email: herdapratama@gmail.com
• Phone: +6282184801976

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.