Dumping syndrome after oesophageal atresia repair
Official title: Physiopathology of Dumping Syndrome in Esophageal Atresia
Run by University Hospital, Lille · NCT04522193 · Data updated 2026-11-12
This study will test continuous glucose and heart monitoring plus a gastric emptying scan in babies born with oesophageal atresia to see if these tests detect dumping syndrome and dangerous drops in blood sugar after feeds.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 2 Months to 3 Months |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 2 sites (Lille and 1 other locations) |
| Status | Recruiting |
| Started | February 23, 2024 |
| Main results expected | November 2026 |
| Study ends | November 2026 |
| Registry record updated | December 23, 2025 |
| Trial ID | NCT04522193 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Infants aged 2 to 3 months who were operated at birth for oesophageal atresia type C and who can stop prokinetic drugs at least 72 hours before monitoring are ideal candidates.
✕Probably not a fit
Babies with other causes of dumping syndrome, disorders that alter glycaemic regulation, or those on treatments that modify gastric motility are unlikely to benefit from this protocol's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Dumping syndrome is common after oesophageal atresia repair and can cause dangerous postprandial hypoglycaemia in infants. This protocol enrolls infants aged 2 to 3 months who were operated at birth for type C oesophageal atresia and who are off prokinetic medication. Participants will receive continuous glycemic monitoring (glycemic Holter), continuous cardiac monitoring (Holter ECG), and a gastric emptying scintigraphy at about three months of age. The study aims to correlate feeding-related symptoms with glucose, cardiac, and gastric emptying measures to better understand the mechanisms behind dumping syndrome.
Why it matters
Potential benefit: If successful, the approach could allow earlier diagnosis and more targeted care to prevent post-meal hypoglycaemia and its complications in infants with oesophageal atresia.
How similar studies have gone: Continuous glucose monitoring and gastric emptying scans have been useful in older patients with dumping or gastric motility disorders, but using this combined approach in neonates with oesophageal atresia is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients operated at birth for Oesophageal atresia type C * Aged from 2 to 3 months at inclusion * Off prokinetic treatment (suspended for at least 72 hours) before monitoring Exclusion Criteria: * History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..) * History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete) * Treatment that can modify gastric motility
Where it's running
-
Hôpital Jeanne de Flandre - Pôle enfant, CHU de Lille
Lille, France Recruiting -
Hôpital Jeanne de Flandres
Lille, France Not yet recruiting
Study contacts
- Principal investigator: Madelaine AUMAR, MD — University Hospital, Lille
- Study coordinator: Madelaine AUMAR, MD
- Email: madeleine.aumar@chru-lille.fr
- Phone: 0320445962
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
See if Continuous Glucose Monitoring can help diagnose dumping syndrome after esophagectomy
Researchers are testing whether a wearable continuous glucose monitor can help spot dumping syndrome in people who had esophageal cancer surgery with a stomach tube reconstruction.
-
Continuous glucose monitoring with iCan i3 for late dumping after Roux-en-Y gastric bypass
This trial will test whether the iCan i3 continuous glucose monitor can detect low blood sugar better than fingerstick checks in adults with late dumping syndrome after Roux-en-Y gastric bypass.
-
Arginine and ADMA levels during recovery from neonatal abdominal surgery
This will test whether blood levels of arginine and ADMA can help predict recovery and complications in babies born after 35 weeks who need abdominal surgery in the first five days of life.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.