Dual-task exercise for teens with pediatric-onset multiple sclerosis
Official title: The Effect of Dual-Task Training on Motor and Cognitive Functions in Pediatric-Onset Multiple Sclerosis Patients
Run by Istanbul University - Cerrahpasa · NCT07571304 · Data updated 2026-11-12
This trial tests whether an 8-week dual-task exercise program helps teens aged 12–18 with pediatric-onset multiple sclerosis improve movement and thinking skills compared with standard functional exercise.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years to 18 Years |
| Sex | All |
| Enrollment | 22 (estimated) |
| Sponsor | Istanbul University - Cerrahpasa Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | April 1, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | April 1, 2027 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT07571304 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 12–18-year-olds diagnosed with pediatric-onset multiple sclerosis by the 2017 revised McDonald criteria with EDSS <6, no relapse or corticosteroid use in the prior 3 months, and no major orthopedic, neurological, systemic, or severe visual problems.
✕Probably not a fit
Patients with EDSS ≥6, recent relapse or steroid treatment within 3 months, significant additional neurological or orthopedic conditions, or severe visual impairment are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center randomized controlled trial will enroll 20 adolescents (12–18 years) with pediatric-onset multiple sclerosis and EDSS <6, randomized 1:1 to a dual-task exercise program or a dose-matched conventional functional exercise program. Both groups receive 16 supervised sessions (45 minutes each) delivered twice weekly over 8 weeks, with outcomes measured at baseline and after the intervention. The dual-task program combines simultaneous motor and cognitive tasks to train integrated skills, while the control program focuses on conventional motor and functional exercises alone. Primary outcomes include motor function, balance, fatigue, and cognitive measures such as processing speed and attention.
Why it matters
Potential benefit: If successful, the program could improve balance, mobility, processing speed, and independence in daily activities for adolescents with pediatric-onset MS.
How similar studies have gone: Dual-task training has shown benefits in adults with multiple sclerosis, but evidence specifically in pediatric-onset MS is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of pediatric-onset multiple sclerosis according to the 2017 revised McDonald criteria Age between 12 and 18 years Expanded Disability Status Scale (EDSS) score \< 6 Exclusion Criteria: * Additional orthopedic problem affecting mobility Significant blurred vision affecting vision Any other neurological or systemic disease besides PBMS Relapse or corticosteroid treatment within the last 3 months
Where it's running
-
Istanbul University-Cerrahpaşa, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Istanbul, Turkey
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Yonca Zenginler Yazgan
- Email: yoncazenginler@gmail.com
- Phone: +905326006294
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.