Driving pressure adjustment for high-frequency jet ventilation during tumor ablation
Official title: Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology - A Randomized, Controlled, Multicenter Study
Run by Nantes University Hospital · NCT07408375 · Data updated 2026-11-12
This study will test whether using a height-based driving pressure for high-frequency jet ventilation improves breathing stability during thermal ablation in adults with non-brain solid tumors.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 560 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 7 sites (Lyon and 6 other locations) |
| Status | Recruiting |
| Started | March 13, 2026 |
| Main results expected | March 13, 2028 |
| Study ends | March 13, 2028 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT07408375 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) scheduled for thermal ablation of a non-central-nervous-system solid tumor under high-frequency jet ventilation who can give informed consent and meet airway and general eligibility criteria.
✕Probably not a fit
Patients who are pregnant or breastfeeding, have had a pneumonectomy, require an endotracheal tube smaller than 6.5 mm, are under guardianship, or cannot understand French are not likely to be eligible or to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients undergoing percutaneous thermal ablation of solid tumors under general anesthesia will receive high-frequency jet ventilation with the driving pressure randomly assigned on the day of procedure to 1.4, 1.9, 2.4 bars, or a height-based customized setting. The trial measures respiratory function and motion control during the ablation to see how driving pressure affects imaging localization and procedure precision. High-frequency jet ventilation delivers small tidal volumes at high frequency to minimize respiratory movement while maintaining oxygenation. The goal is to determine whether a height-adjusted pressure reduces motion and improves conditions for complete tumor destruction while protecting adjacent organs.
Why it matters
Potential benefit: If successful, height-based driving pressure settings could reduce respiratory motion during ablation, improving targeting accuracy and potentially lowering damage to nearby organs.
How similar studies have gone: High-frequency jet ventilation is an established technique to reduce respiratory motion during image-guided ablation, but using a height-based driving pressure is a relatively novel, less-tested approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Patient undergoing thermal ablation of a solid tumor under HFJV. * Patient who has given their consent. * Patient covered by a social security scheme. Exclusion Criteria: * Patient under guardianship or curatorship. * Patient who does not understand French. * Pregnant and breastfeeding woman * Patient who has had a pneumonectomy * Patient requiring an endotracheal tube smaller than 6.5
Where it's running
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CHU de Lyon
Lyon, France Recruiting -
CHU de Nantes
Nantes, France Recruiting -
CHU de Poitiers
Poitiers, France Recruiting -
ICO Unicancer
Saint-Herblain, France Recruiting -
Institut Gustave Roussy
Villejuif, France Recruiting -
CHU de Nîmes
Nîmes, France Not yet recruiting
Show 1 more location
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Hôpital Européen Georges Pompidou (HEGP)
Paris, France Not yet recruiting
Study contacts
- Study coordinator: Nathalie DESFRICHES-DORIA
- Email: nathalie.desfrichesdoria@chu-nantes.fr
- Phone: 0244768434
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.