Dorso-lateral Prefrontal Cortex Stimulation for Motor Conversion Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the efficacy of non-invasive brain stimulation targeting the dorso-lateral prefrontal cortex in patients with motor conversion disorder. The study aims to activate this brain region to restore executive control and improve motor symptoms, which are often debilitating and resistant to traditional treatments. Patients will undergo neurostimulation with non-implanted electrodes and will be followed for six months to assess outcomes. The trial is based on previous findings linking hypoactivation of the prefrontal cortex to persistent motor disability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patient must have given his/her informed and signed consent.
* The patient is at least (≥) 18 years old and 65 years old at the most (≤). The risk of an increased frequency of somatic comorbidity, drug co-prescription, and cognitive impairment prompts us to limit recruitment to age 65 in this study.
* The patient is hospitalized or followed in consultation.
* Patient is available for a follow-up of 6 months.
* With current DSM-5 criteria for conversion disorder during more than 10 days, motor type (i.e. with paralysis or motor weakness) and initial EDSS score ≥ 3 or initial WHO Score is ≥ 2

Exclusion Criteria:

* The patient is participating in another interventional trial.
* The patient refuses to sign the consent.
* It is impossible to correctly inform the patient.
* The patient is pregnant or breastfeeding.
* Specialized neurological clinical examination and the performing of brain and medullary MRI reveal an organic neurological involvement.
* Current episode of mania, hypomania, diagnosis of substance abuse/dependence (excluding smoking), diagnosis of schizophrenia over lifetime, severe neurological pathology (epilepsy, stroke, brain tumor).
* Patient with a contraindication to MRI (for patients enrolled in Nîmes).
* Acute eczema at the electrodes loci.

Where it's running

• Centre Hospitalier Universitaire
  Nîmes, Gard, France Recruiting
• Hôpital La Colombière Service de Psychiatrie
  Montpellier, Hérault, France Not yet recruiting
• CHU de Montpellier Hôpital Gui De Chauliac Service de Neurologie
  Montpellier, Hérault, France Not yet recruiting
• Hôpital Lapeyronie
  Montpellier, Hérault, France Not yet recruiting
• Hospices Civils de Lyon Hôpital Edouard Herriot
  Lyon, France Not yet recruiting
• CHU de Nantes
  Nantes, France Not yet recruiting

Study contacts

• Principal investigator: Ismael CONEJERO, Dr. — CHU de Nîmes (Nîmes University Hospital)
• Study coordinator: Ismael CONEJERO, Dr.
• Email: ismael.conejero@gmail.com
• Phone: 07 70 21 62 38

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.