Does mobilization with movement lower inflammation in knee osteoarthritis?
The Effect of Mobilization With Movement Versus Sham Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.
This trial will try mobilization with movement plus exercise and education to see if it reduces pain and blood markers of inflammation in adults with moderate to severe knee osteoarthritis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Jazan Government |
| Locations | 1 site (Jizan, Jazan Region) |
| Trial ID | NCT07166068 on ClinicalTrials.gov |
What this trial studies
This randomized, controlled trial will enroll 40 adults with Kellgren-Lawrence grade 2–3 knee osteoarthritis and pain greater than 3/10. Participants will be randomly assigned to receive either mobilization with movement (MWM) or a sham mobilization, with both groups also receiving standard exercise and education. Treatments will be delivered twice weekly for four weeks, and outcomes will be measured before and after the intervention period. Primary outcomes include blood inflammatory markers (e.g., CRP, ESR), self-reported pain, and knee function.
Who should consider this trial
Good fit: Adults aged 18 or older with clinically diagnosed unilateral or bilateral knee OA (Kellgren-Lawrence grade 2–3), pain greater than 3 on a VAS, and a BMI between 18.5 and 30 kg/m² are ideal candidates.
Not a fit: Patients with inflammatory arthritides (like rheumatoid arthritis or gout), recent knee surgery, recent systemic or intra‑articular steroid or hyaluronic acid injections, recent significant infections, contraindications to mobilization, or BMI outside 18.5–30 may not receive benefit or be eligible.
Why it matters
Potential benefit: If successful, the approach could reduce knee pain and systemic inflammation, improving function and symptom management for people with knee osteoarthritis.
How similar studies have performed: Previous trials of MWM and other manual therapies have demonstrated improvements in pain and function in knee OA, but evidence that these techniques change systemic inflammatory biomarkers is limited and mixed.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of unilateral or bilateral knee osteoarthritis (OA) according to the criteria of the American College of Rheumatology * Age ≥ 18 years * Kellgren-Lawrence grade 2 or 3 knee OA * Pain intensity \> 3 on a visual analogue scale (VAS) * Body mass index (BMI) between 18.5 and 30 kg/m² Exclusion Criteria: * Knee or lower limb surgery within the last six months. * Significant joint disorders (e.g., rheumatoid arthritis, gout, or other inflammatory arthritis). * Recent significant acute infections. * Contraindications to mobilization with movement. * Current or recent use systemic glucocorticoids, intra-articular glucocorticoid injections or intra-articular hyaluronic acid injections.
Where this trial is running
Jizan, Jazan Region
- Jazan University Hospital — Jizan, Jazan Region, Saudi Arabia (Recruiting)
Study contacts
- Study coordinator: Abdulraouf Ayoub, PT
- Email: aayoub@jazanu.edu.sa
- Phone: +966500057742
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.