Does luteal support improve outcomes in modified natural-cycle frozen embryo transfer?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized controlled trial comparing three approaches for modified natural-cycle frozen embryo transfer: no luteal support, vaginal progesterone, and progesterone plus hCG. Eligible participants planning a single good-quality blastocyst transfer are randomized and undergo a modified natural FET protocol with monitoring of follicle development. Primary outcomes include implantation and clinical pregnancy rates, with follow-up for pregnancy continuation and likely live birth. The trial is conducted at several IVF centers in Hungary and uses standard inclusion/exclusion criteria to select participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-40 years at the time of vitrification
* At least one good quality blastocyst frozen
* Planned 1 blastocyst transfer
* \<3 failed previous ETs
* Cycle length between 21-35 days
* Body mass index (BMI): 18-35 kg/m2
* Intact uterine cavity based on hysteroscopy, hysteron-salpingogram, salina sonohysterogram
* Consent to participate

Exclusion Criteria:

* Age \<18 of over 40 at the time of vitrification
* BMI: \<18 kg/m2 or \>35 kg/m2
* Planned transfer of more than 1 embryo
* Irregular cycles (\<21 or \>35 days)
* Use of a protocol other than the modified natural cycle frozen embryo transfer
* Lack of good morphology blastocysts
* No evidence for spontaneous follicle development (no dominant (\>17 mm) follicle by day 20 of cycle)
* Patient with a history of recurrent miscarriages
* Presence of a hydrosalpinx
* Irregular uterine cavity
* Positive test for HIV, hepatitis B or C
* Lack of consent

Where it's running

• Dunamenti REK Istenhegyi IVF Center
  Budapest, Budapest, Hungary Recruiting
• Dunamenti REK Gyor IVF Center
  Győr, Gyor, Hungary Recruiting
• University of Pecs, Dept. OBGYN, Reproductive Center
  Pécs, Pecs, Hungary Recruiting
• University of Szeged, Reproductive Medicine Institute
  Szeged, Szeged, Hungary Recruiting
• Dunamenti REK Tapolca IVF Center
  Tapolca, Tapolca, Hungary Recruiting

Study contacts

• Study coordinator: Peter Kovacs MD medical director Dunamenti REK Istenhegyi IVF Center, MD, PhD
• Email: peterkovacs1970@hotmail.com
• Phone: +3612022802

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Endometrial Waves and Pregnancy in FET Cycles with Hormone Therapy

  This study tests whether patterns of uterine contractions during hormone-prepared frozen embryo transfer affect pregnancy outcomes.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City · NCT07675213

• Comparing two vaginal progesterone forms for frozen embryo transfer

  This compares whether soft vaginal progesterone capsules are easier to use, better tolerated, and give similar pregnancy results as vaginal progesterone pessaries for women having frozen embryo transfer.

  Recruiting Instituto Valenciano de Infertilidade de Lisboa · Lisbon · NCT07461909

• FET-LET-2x2: Testing natural vs medicated natural cycles for frozen embryo transfer

  This study tests four approaches to preparing the uterus for frozen embryo transfer to see which yields the best pregnancy rate in women undergoing IVF.

  Recruiting University of Novi Sad · Novi Sad · NCT07425990

• How frozen embryo transfer preparation affects uterine wave activity

  We will test whether preparing for frozen embryo transfer with hormones or using a natural cycle changes uterine contractions in women having FET.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City and 1 other locations · NCT07358468

• Levothyroxine for women with mild (subclinical) hypothyroidism having IVF/ICSI and frozen embryo transfer

  This project will try giving low‑dose levothyroxine to women with subclinical hypothyroidism undergoing IVF/ICSI with frozen embryo transfer to see if it improves pregnancy outcomes.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City, Ho Chi Minh and 1 other locations · NCT07257250

• Single-step versus multi-step blastocyst warming for frozen embryo transfer

  This tests whether a simpler single-step thawing solution works as well or better than the standard multi-step warming for women having frozen blastocyst transfers.

  Recruiting Mỹ Đức Hospital · Ho Chi Minh City, City · NCT07088640

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.