Do medicines that lengthen the heart's QT interval cause serious heart problems in hospitalized adults?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use anonymized electronic medical record data from the Ontario GEMINI network and Epic‑Dovetale, covering more than 990,000 eligible adult hospital admissions, to compare patients who experienced a major adverse cardiac event (MACE) with those who did not. The team will perform a nested case‑control analysis and time-varying exposure analyses to measure whether exposure to listed 'known' QT‑prolonging medications during hospitalization is associated with a composite MACE outcome of death, non-fatal cardiac arrest, ventricular arrhythmia, or syncope. In addition, machine‑learning algorithms will be trained to predict QTPmed-associated MACE and to determine the relative importance of predictors. Results will be used to improve the accuracy and clinical usefulness of medication safety alerts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients 18 years of age or older
* Admitted to St. Joseph's Healthcare Hamilton or GEMINI hospitals between December 2017 and March 2025

Exclusion Criteria:

* Patients \<18 years old
* Outpatient encounters

Where it's running

• St. Joseph's Healthcare Hamilton
  Hamilton, Ontario, Canada Recruiting
• Gemini
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Anne M Holbrook — St. Joseph's Healthcare Hamilton
• Study coordinator: Anne M Holbrook, MD,PharmD,MSc,FRCPC
• Email: cptres@mcmaster.ca
• Phone: 905-522-1155

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.