Do airway mucus plugs cause lung scarring in people with COPD undergoing lung cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center prospective case-control study comparing COPD patients (FEV1/FVC <0.70) to surgical controls with normal spirometry who are undergoing radical lung cancer resection. During surgery investigators will collect distal non-tumorous lung tissue and airway mucus for histological and molecular analysis. Mucus plug burden will be quantified with AB-PAS staining and fibrosis with Masson staining, while expression of EMT markers, fibrotic markers, and the mechanosensitive channel Piezo1 will be measured. The study involves only biospecimen collection and laboratory analyses, with no interventional treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ① Age ≥ 18 years old;

  * Planned radical resection for lung cancer, with postoperative pathological diagnosis of primary lung cancer;

    * During surgery, non tumor lung tissue at a distance of ≥ 5 cm from the tumor edge can be obtained; ④ Case group: Preoperative pulmonary function examination confirmed diagnosis of COPD (FEV ₁/FVC\<0.70); ⑤ Control group: Preoperative lung function was normal (FEV ₁/FVC ≥ 0.70), with no history of COPD; ⑥ The subjects are able to understand and sign the informed consent form

Exclusion Criteria:

* ① Clear presence of other interstitial lung diseases (ILD) or idiopathic pulmonary fibrosis before or during surgery （IPF）、 Fibrosis after pneumoconiosis or tuberculosis;

  * Active pulmonary infections (such as bacterial pneumonia, fungal infections, active tuberculosis);

    * Having received neoadjuvant radiotherapy or chemotherapy, which may affect the morphology or molecular results of distal lung tissue; ④ Combined severe immunodeficiency or long-term systemic immunosuppressive therapy (such as glucocorticoids ≥ 20 mg/d, More than 4 weeks);

      * Merge with other serious systemic diseases (such as advanced heart failure, end-stage renal disease), affecting study compliance or Survival expectation; ⑥ Pregnant or lactating women; ⑦ Refusing to sign the informed consent form or deemed unsuitable by the researcher to participate in the study.

Where it's running

• Zhongshan hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: shengyu hao
• Email: janet9yu@163.com
• Phone: 18359181031

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.