DNA methylation test for diagnosing thyroid nodules after fine-needle aspiration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project applies a diagnostic DNA methylation signature (DDMS) to leftover and newly collected fine-needle aspiration (FNA) samples from patients with thyroid nodules to determine whether methylation patterns distinguish benign from malignant lesions. It combines retrospective analysis of previously collected FNA specimens with prospective collection from current patients, analyzing all samples using the DDMS assay. Participants whose samples are tested are followed yearly for five years to track clinical outcomes and confirm diagnoses. The primary goal is to validate the DDMS as a diagnostic tool specifically for nodules with indeterminate cytology (Bethesda III–V).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients undergoing FNA for thyroid nodule diagnosis.
* Any race and ethnicity are eligible for the study.
* Patient should have thyroid nodule(s) with indeterminate diagnosis after FNA (Bethesda category of indeterminate FNA \[III-V\]).

Where it's running

• City of Hope Medical Center
  Duarte, California, United States Recruiting

Study contacts

• Principal investigator: Maria Hahn, PhD — City of Hope Medical Center

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.