Dissociation-focused cognitive behavioral therapy for people with dissociative disorders
Official title: Evaluation of the Efficacy of Dissociation-Focused Cognitive Behavior Therapy: a Multicenter Randomized Controlled Trial
Run by University Hospital, Tours · NCT06917209 · Data updated 2026-11-12
This program tests whether dissociation-focused cognitive behavioral therapy (DF-CBT) helps adults with dissociative disorders reduce their dissociative symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | University Hospital, Tours Academic / other |
| Locations | 8 sites (Angers and 7 other locations) |
| Status | Recruiting |
| Started | May 16, 2025 |
| Main results expected | November 16, 2028 |
| Study ends | May 16, 2029 |
| Registry record updated | July 9, 2026 |
| Trial ID | NCT06917209 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a diagnosed dissociative disorder who can attend psychotherapy and provide informed consent are ideal candidates.
✕Probably not a fit
People with current substance use disorder (except tobacco), major neurodevelopmental or certain severe psychiatric disorders, cognitive deficits, ongoing psychotherapy, or on benzodiazepines are unlikely to be eligible or benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional program delivers dissociation-focused cognitive behavioral therapy (DF-CBT) to adults diagnosed with dissociative disorders at several French university hospitals. Participants who meet eligibility criteria receive structured psychotherapy sessions and must have stable psychiatric medication if applicable. The protocol excludes people with active substance use disorder, certain severe psychiatric diagnoses, current psychotherapy, cognitive deficits, or benzodiazepine treatment. Previous exploratory, uncontrolled work has suggested DF-CBT may be promising, but controlled evidence is still needed.
Why it matters
Potential benefit: If effective, DF-CBT could reduce dissociative symptoms and improve daily functioning for people with dissociative disorders.
How similar studies have gone: Uncontrolled exploratory studies have reported promising results for DF-CBT, but randomized controlled evidence is lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥ 18 years * Membership of a social security scheme * Participant's express consent * Have at least one diagnosis of dissociative disorder among the following: depersonalization/derealization disorder, dissociative identity disorder, unspecified dissociative disorder. * Be able to carry out psychotherapy sessions. * If taking psychiatric medication, treatment must have been stable for at least 30 days. Exclusion Criteria: * Present one of the following current diagnoses: substance use disorder (excluding tobacco), neurodevelopmental disorder, anorexia nervosa, severe depressive disorder, schizophrenia spectrum disorder, bipolar disorder, personality disorder other than borderline personality disorder. * Present cognitive deficits. * Be engaged in psychotherapeutic work. * Be undergoing benzodiazepine treatment. * Pregnant women and breastfeeding women
Where it's running
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Centre Régional du Psychotraumatisme CRP / CHRU TOURS
Tours, France Recruiting -
Unité de Neuromodulation / CHU de Tours
Tours, France Recruiting -
Psychiatrie / CHU ANGERS
Angers, France Not yet recruiting -
Centre régional du Psychotraumatisme des Hauts de France / CHU LILLE
Lille, France Not yet recruiting -
Urgences psychiatrique / CHU MONTPELLIER
Montpellier, France Not yet recruiting -
Unité de neuromodulation en psychiatrie / CHU NANTES
Nantes, France Not yet recruiting
Show 2 more locations
-
Centre départemental de Psychotraumatologie (unité TCC) / ORLEANS
Orléans, France Not yet recruiting -
Centre Régional du Psychotraumatisme du Grand Est / CHU STRASBOURG
Strasbourg, France Not yet recruiting
Study contacts
- Principal investigator: Wissam EL HAGE, MD-PhD — Unité de Neuromodulation / CHU de Tours
- Study coordinator: Alexis VANCAPPEL, PhD
- Email: alexis.vancappel@univ-tours.fr
- Phone: 02.34.37.89.47
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.