Direct 3D-printed aligners for moving upper and lower incisor crowns
Official title: Comparison of Predicted and Achieved Crown Movements in Adult Spacing Cases Treated With 3D Direct-printed Aligners: A Prospective Clinical Trial
Run by Suez Canal University · NCT07273435 · Data updated 2026-11-12
This study tests whether direct 3D-printed aligners can achieve the planned crown movement of upper and lower incisors in adults with spacing.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 23 (estimated) |
| Sponsor | Suez Canal University Academic / other |
| Locations | 3 sites (Banī Suwayf and 2 other locations) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | June 1, 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | December 9, 2025 |
| Trial ID | NCT07273435 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–45 with full permanent dentition (excluding third molars), generalized or localized anterior spacing, Angle Class I or mild Class II relationships, and no significant periodontal disease are ideal candidates.
✕Probably not a fit
Patients with crowding, missing permanent teeth, active periodontal disease, severe skeletal Class II/III discrepancies, or medical conditions affecting bone metabolism are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will enroll 23 adult patients with anterior spacing and normal skeletal relationships at three Egyptian university dental clinics. Each patient will receive intraoral scans and a 3D treatment simulation to plan crown movements, after which direct 3D-printed aligners will be fabricated. Patients will wear the aligners (warmed before insertion to activate shape memory) and change them weekly while clinicians compare actual tooth positions to the predicted movements. Outcomes focus on the accuracy and efficiency of crown movement during space closure for upper and lower incisors.
Why it matters
Potential benefit: If successful, the approach could deliver more accurate tooth movements with direct-printed aligners, potentially reducing the need for refinements and shortening treatment time.
How similar studies have gone: Preliminary reports and small series suggest 3D-printed aligners are feasible, but there are limited data specifically quantifying crown-movement accuracy compared with digital predictions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18- 45 years old. * Non- extraction treatment. * Angle Class I or Class II dental malocclusion with generalized or localized anterior spacing. * Normal probing depth. Exclusion Criteria: * Active periodontal disease. * Crowding cases. * Systemic diseases or medications that alter bone metabolism or tooth movement.
Where it's running
-
Beni-Suef University
Banī Suwayf, Egypt Recruiting -
British University in Egypt
Cairo, Egypt Recruiting -
Suez Canal University
Ismailia, Egypt Recruiting
Study contacts
- Principal investigator: Rim M Fathalla, PhD of Orthodontics — Suez Canal University
- Study coordinator: Rim M Fathalla, PhD of Orthodontics
- Email: rim_fathalla@dent.suez.edu.eg
- Phone: 00201222726567
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.